VEGF和Ki-67在复发性小脑血管母细胞瘤中的临床意义  

The relationship of VEGF and Ki-67 expressions in the recurrent cerebellar hemangiblastoma

作　　者：滕宏伟[1] 薛新潮[1] 

机构地区：[1]滨海县人民医院神经外科,江苏224500

出　　处：《交通医学》2012年第1期36-38,共3页Medical Journal of Communications

摘　　要：目的:探讨VEGF和Ki-67在复发的小脑血管母细胞瘤中表达的意义。方法:采用免疫组化(SP法)检测VEGF和Ki-67在18例复发的小脑血管母细胞瘤组织中和43例未复发的小脑血管母细胞瘤中的表达,采用SPSS13.0统计软件分析其表达的差异。结果:VEGF、Ki-67在复发组的阳性表达率分别为88.9%(16/18)和83.1%(15/18);VEGF、Ki-67在未复发组的阳性表达率为74.4%(32/43)和62.7%(27/43),两者之间差异有统计学意义(P<0.05)。结论:VEGF促使肿瘤血管形成,对病变的复发产生影响;联合检测VGFR和Ki-67,对小脑血管母细胞瘤的预后判断有一定帮助。Objective：To evaluate the relationship of VEGF and Ki-67 expressions in the recurrent cerebellar hemangiblastoma.Methods：The differential expressions of VEGF and Ki-67 were detected by SP immunohistochemical staining in 18 cases of recurrent cerebellar hemangioblastoma and 43 cases without recurrence.Results：Total positive expression rates of VEGF and Ki-67 in recurrent cerebellar hemangioblastoma were 88.9%（16/18） and 83.3%（15/18）.However,the total positive expression rates of VEGF and Ki-67 in the cases without recurrence were 74.4%（32/43） and 62.7%（27/43）.There was statistic significance between the two groups（P0.05）.Conclusion：The VEGF can promote the tumor angiogenesis and the relapse of the tumor.Meanwhile,the VEGF and Ki-67 can help the prognosis of cerebellar hemangiblastoma.

关 键 词：复发性小脑血管母细胞瘤 血管通透性因子 细胞增殖期特异性表达的核抗原 

分 类 号：R739.4[医药卫生—肿瘤]