消化道恶性肿瘤患者血清可溶性肿瘤坏死因子受体-Ⅰ的检测及其临床评价  

Detection and its clinical significance of serum soluble tumor necrosis factor receptor-Ⅰ in patients with malignant carcinoma of digestive system

作　　者：王瑞华[1] 许培仁[1] 陈树恩 赵冬梅[1] 

机构地区：[1]开封医学高等专科学校附属淮河医院消化内科,475000

出　　处：《中国实用内科杂志》2000年第2期107-108,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的　了解可溶性肿瘤坏死因子受体 -Ⅰ (sTNFR -Ⅰ )在消化道恶性肿瘤患者中的临床意义。方法　应用双抗体夹心ELISA法 ,对 37例食管癌、41例胃癌、30例大肠癌患者血清sTNFR -Ⅰ水平进行了检测。结果　三组肿瘤患者血清sTNFR -Ⅰ水平显著高于对照组 ,且随肿瘤临床病理分期增加而增高 ,有转移者显著高于无转移者。手术切除肿瘤后sTNFR -Ⅰ水平下降 ,肿瘤复发时sTNFR -Ⅰ水平上升。结论　检测血清sTNFRObjective To define the clinical significance of serum soluble tumor necrosis factor receptor-Ⅰ(sTNFR-Ⅰ) in patients with malignant carcinoma of digestive system.Methods Measure serum levels of sTNFR-Ⅰusing ELISA technique in 37 patients with esophaged carcinoma(EC),41 patients with gastric carcinoma(GC),30 patients with colorectal carcinoma(CC).Results The levels of sTNFR-Ⅰwere significantly higher in patients with EC,GC and CC than in controls .The more advanced the clinicopathologic stage of malignant tumor,the higher serum levels of sTNFR-Ⅰ.Metastatic patients with EC,GC and CC showed significantly higher mean levels of sTNFR-Ⅰthan in those without metastasis.Levels of sTNFR-Ⅰwere significantly lower in patients with malignant tumor after surgical removal of tumor .A rise again in serum sTNFR-Ⅰ level were found to correlate with tumor recurrence.Conclusion This study suggests that measurement of serum sTNFR-Ⅰ in patients with malignant carcinoma of digestive system is useful for the diagnosis and prognosis.391 cases with doubted tubercnlosis by roengenogram of chest and to compare their results in different ages and in different sexes.Method:Operated by World Book of China Controling Tubcrculosis Program Loaded Fril The Eord Band.Results:The plsitive rate of morning sutum goes up to 41 41 percent and that of instant sputum 14 23 percent with remarkable differences in statistics(X 2=273 77).The paper suggests that the test of morning sputum is an important means in diagnosing pulmonary tuberculosis. Key words:pulmonary tuberculosis;test sputum;comparison

关 键 词：消化道肿瘤 STNFR-I 血清诊断 

分 类 号：R735.04[医药卫生—肿瘤]