PET／CT显像在构建肿瘤放疗生物靶区中的作用  

Role of PET/CT functional imaging on constructing a tumor radiotherapeutic biological target vol-I^lne

作　　者：吕文天[1] 于金明[1] 

机构地区：[1]山东省肿瘤医院放疗科,济南300070

出　　处：《中华核医学与分子影像杂志》2012年第2期158-160,共3页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：在调强放疔的常规分割研究中，肿瘤靶区内放射敏感性不同的区域所需要的放疗剂量也应该不尽相同。对于放疗中肿瘤局部或全部达到CR的靶区是否有残留的肿瘤细胞是实施放疗补量的重要前提。这使以CT解剖影像学为基础的放疗靶区研究成为瓶颈。对此，通过PET／CT功能性成像研究实施的、以反映与肿瘤细胞放射敏感性和细胞增殖有关的细胞代谢、乏氧和细胞周期各时相DNA动态变化的生物靶区构建研究，将成为重要的研究领域。In studies on intensity modulated radiotherapy with conventional fraetionation, different radiosensitivity areas require different irradiation doses. In tumor radiotherapy areas CR, boosts in radiotherapy doses should be determined according to whether there are survived tumor cells or not. To those survived cells, CT imaging has become the key tool to delineate the radiotherapy target. Thus, the study on the construction of biological target volume with PET/CT functional imaging, which could reflect either radiosensitivity or cell proliferation-related cell metabolism, anoxia and DNA number of various cell cycle phases, is an important research area.

关 键 词：肿瘤 放射疗法 生物靶区 体层摄影术 发射型计算机 体层摄影术 x线计算机 

分 类 号：R730.5[医药卫生—肿瘤]