77例T细胞非霍奇金淋巴瘤的临床病理特点和免疫表型分析  

The clinicopathologic features and immunophenotypes of T-cell non-Hodgkin′s lymphoma:an analysis of 77 cases

作　　者：赵伟[1] 陈陆俊[1] 田波[1] 谈炎[1] 鲁常青[1] 

机构地区：[1]常州市第一人民医院病理科,江苏省213003

出　　处：《江苏医药》2012年第7期812-814,F0002,共4页Jiangsu Medical Journal

摘　　要：目的探讨T细胞非霍奇金淋巴瘤的临床病理特点和免疫表型。方法对77例T细胞非霍奇金淋巴瘤进行苏木素和伊红染色(HE)和免疫组织化学检查,按WHO 2008年《造血和淋巴组织肿瘤的病理学和遗传学》标准进行分类。结果 77例T细胞非霍奇金淋巴瘤中,鼻型结外NK/T细胞淋巴瘤32例(41.6%),非特异性外周T细胞淋巴瘤20例(26.0%),间变性大细胞淋巴瘤11例(14.3%),前驱T淋巴细胞淋巴瘤9例(11.7%)。结论 T细胞非霍奇金淋巴瘤中,最常发生的亚型是鼻型结外NK/T细胞淋巴瘤,其次为非特异性外周T细胞淋巴瘤、间变性大细胞淋巴瘤和前驱T淋巴细胞淋巴瘤。其中,鼻型结外NK/T细胞淋巴瘤预后较差,而间变性大细胞淋巴瘤预后相对较好。Objective To study the clinicopathologic features and immunophenotypes of T-cell non-Hodgkin′s lymphoma.Methods Seventy-seven of T-cell non-Hodgkin′s lymphomas were studied by light microscopy and immunohistochemistry.All cases were reclassified according to the new WHO classification of lymphomas.Results Of 77 T-cell non-Hodgkin′s lymphomas,32（41.6%） cases were extranodal NK/T cell lymphomas of nasal type,20（26.0%） cases were nonspecific peripheral T cell lymphomas,11（14.3%） cases were anaplastic large cell lymphomas and 9（11.7%） cases were precursor T lymphoblastic lymphomas.Conclusion Among T-cell non-Hodgkin’s lymphomas,extranodal NK/T cell lymphoma of nasal type is the most common subtype.The other main subtypes conclude nonspecific peripheral T cell lymphomas,anaplastic large cell lymphomas and precursor T lymphoblastic lymphomas.The patients with extranodal NK/T cell lymphomas of nasal type have poor prognosis,while those with anaplastic large cell lymphomas have favorable prognosis.

关 键 词：淋巴瘤 T细胞 免疫表型 

分 类 号：R733[医药卫生—肿瘤]