腋下淋巴结阴性乳腺癌患者人表皮生长因子受体-2表达的临床病理特征及预后  

Clinicopathological characteristics and prognosis of Her-2 expression in axillary lymph node-negative breast cancer patients

作　　者：冯爱强[1] 张力莹[1] 冯浩[1] 张彦武[1] 王举[1] 胡花丽[1] 

机构地区：[1]郑州大学第三附属医院乳腺科,450052

出　　处：《中国实用医刊》2012年第8期37-39,共3页Chinese Journal of Practical Medicine

摘　　要：目的研究腋下淋巴结阴性乳腺癌患者临床病理特征及其与人表皮生长因子受体-2（Her-2）表达的相关性及预后分析。方法收集自2003年至2009年期间郑州大学第三附属医院收治的278例原发性乳腺癌患者的临床资料，经病理检查证实腋下淋巴结为阴性。回顾性分析患者的临床病理特征、复发转移及生存情况，并进一步分析乳腺癌的预后影响因素。结果278例原发性腋下淋巴结阴性乳腺癌患者中，肿块大小、雌激素受体（ER）及孕激素受体（PR）表达状态与Her-2蛋白表迭水平明显相关（P〈0．05）。另外，绝经状态、肿块大小、ER及PR表达状态与患者的5年无病率和5年生存率明显相关（P〈0．05）。结论ER及PR可作为预测腋下淋巴结为阴性的乳腺癌患者远期生存的重要指标，为乳腺癌治疗方案提供参考依据。Objective To investigate the correlation of Her-2 expression with the clinicopathological characteristics and prognosis of axillary lymph node-negative breast cancer patients. Methods The clinical data of 278 patients with axillary lymph node-negative breast cancer between 2003 and 2009 admitted in the third affiliated hospital of Zhengzhou University were collected. The clinicopathological characteristics, distant metastasis and survival information were retrospectively analyzed, and then the prognostic influencing factors of breast cancer were further investigated. Results Among the 278 patients with axillary lymph node-negative breast cancer, the level of Her-2 expression was significantly correlated with tumor size, estrogen receptor and progesterone receptor expression levels （P 〈0. 05）. Morever, the menopausal status, tumor size, and the expressions of ER and PR were significantly correlated with five-years disease-free survival rate and five-years overall survival rate （P 〈 0.05 ）. Conclusions ER and PR can serve as important indicator of the long-term survival state of patients with breast cancer, and provide reference for making therapy.

关 键 词：乳腺癌 人表皮生长因子受体-2 高表达 腋下淋巴结 预后 

分 类 号：R737.9[医药卫生—肿瘤]