细胞色素P4502E1基因RsaⅠ/PstⅠ位点多态性与中国人食管癌发病风险关系的Meta分析  

CYP2E1 RsaⅠ/PstⅠpolymorphism contributes to esophageal cancer risk in Chinese populations:A meta-analysis

作　　者：冷卫东[1] 胡媛媛[1] 王珏[2,3] 龚恒[4] 牛玉明[1] 曾宪涛[1] 

机构地区：[1]湖北医药学院附属太和医院口腔医学中心颌面-头颈外科,湖北十堰442000 [2]湖北医药学院附属太和医院病理科,湖北十堰442000 [3]湖北医药学院形态学实验室 [4]湖北医药学院附属太和医院耳鼻咽喉科,湖北十堰442000

出　　处：《中华临床医师杂志（电子版）》2012年第8期113-118,共6页Chinese Journal of Clinicians(Electronic Edition)

基　　金：湖北医药学院附属太和医院2011年度博士科研启动基金(2011QD01;2011QD05);湖北医药学院2011年度优秀中青年科技创新团队项目(2011CZX01)

摘　　要：目的通过Meta分析的方法系统评价细胞色素P4502E1(CYP2E1)基因RsaⅠ/PstⅠ位点多态性与中国人食管癌发病风险的相关性。方法检索PubMed、Embase、CBM、CNKI、VIP和WANFANG数据库中1990年1月1日至2011年11月30日有关CYP2E1基因多态性与食管癌发病风险关系的文献,进行文献筛选、质量评价和数据提取后,采用RevMan5.1软件进行Meta分析。结果最终纳入18篇病例对照研究共19个试验,其中食管癌患者1663例,对照2603例。Meta分析结果显示CYP2E1基因多态性与食管癌的关联有统计学意义[c2vs.c1:OR=0.64,95%CI=0.50～0.81,P=0.0003;c2/c2vs.c1/c1:OR=0.70,95%CI=0.56～0.89,P=0.003;c1/c2vs.c1/c1:OR=0.54,95%CI=0.38～0.75,P=0.0003;c2/c2vs.(c1/c1+c1/c2):OR=0.73,95%CI=0.58～0.92,P=0.008;(c1/c2+c2/c2)vs.c1/c1:OR=0.48,95%CI=0.34～0.70,P=0.0001];汉族的亚组分析结果也显示CYP2E1基因多态性与食管癌的关联有统计学意义[c2vs.c1:OR=0.71,95%CI=0.57～0.89,P=0.002;c2/c2vs.c1/c1:OR=0.75,95%CI=0.59～0.95,P=0.02;c1/c2vs.c1/c1:OR=0.62,95%CI=0.46～0.84,P=0.002;c2/c2vs.(c1/c1+c1/c2):OR=0.78,95%CI=0.61～0.99,P=0.04;(c1/c2+c2/c2)vs.c1/c1:OR=0.56,95%CI=0.40～0.79,P=0.001]。结论对目前相关研究结果的Meta分析显示CYP2E1基因多态性与中国人群食管癌发生风险具有相关性,其RsaⅠ/PstⅠ位点的c2等位基因可能是食管癌的保护或抑制因素。Objective To evaluate the relation between CYP2E1 Rsa l/Pst I polymorphism and esophageal cancer risk by recta-analysts. Methods A comprehensive search was performed in PubMed, Embase, CBM, CNKI, VIP and WANFANG database to collect the studies which to investigate the relation between CYP2E1 Rsa I/Pst I polymorphism and esophageal cancer r/sk,from January 1,1990 to until November 30,2010. After studies selected, quality assessed, and data extracted, a meta-analysls was performed by using the RevMan 5. 1 software. ResuRs Eighteen case-control studies including nineteen trails involving 1663 cases and 2603 controls were acquired. The pooled OR with 95% CI indicated that CYP2E1 Rsa I/Pst [ polymorphism was significantly related with esophageal cancer risk[ c2 vs. cl ：OR =0, 64,95% CI =0. 50-0. 81 ,P =0. 0003 ;c2/c2 vs. cl/cl ：OR =0. 70, 95% CI=0.56-0.89,P=0.003;cl/c2 vs. cl/c1：0R=0.54,95% CI=0.38-0.75,P=0.0003;c2/c2 vs. （cl/cl ＋ cl/c2） ： OR ：= 0. 73,95 % CI = 0, 58-0. 92, P = 0. 008 ; （ cl/c2 ＋ c2/c2） vs. cl/cl ： OR = 0.48,95% CI = 0. 34- 0. 70 ,P = 0. 00C）1 ] and Hart [ c2 vs. c1 ： OR = 0, 71,95% CI = 0. 57-0. 89, P = 0. 002 ; c2/c2 vs. cl/cl ： OR = 0. 75, 95% C1 =0. 59＇-0. 95 ,P =0.02;cl/c2 vs. cl/cl ：OR =0. 62,95% CI = 0.46-0. 84,P = 0. 002 ;c2/c2 vs. （ cl/cl ＋ el/c2） .OR =0.78,95% CI =0. 61-0.99,P =0. 04; （ cl/c2 ＋ c2/c2）vs, cl/cl ： OR = 0. 56,95% CI =0.40-0. 79, P = 0. 001 ]. Conclusions Based on currently studies, the CYP2E1 Rsa I/Pst I polymorphism is related with esophageal cancer risk,and the c2 allele may be a decreased risk factor for developing esophageal cancer among in Chinese populations.

关 键 词：细胞色素P450CYP2E1 多态性 单核苷酸 食管肿瘤 危险因素 META分析 

分 类 号：R735.1[医药卫生—肿瘤]