近红外光谱技术在激光热疗荷瘤大鼠中的实时监测研究  

Research on the application of near-infrared spectroscopy technology in laser interstitial thermotherapy for rats with glioma

作　　者：王猛[1] 游洋[1] 杨天明[1] 钱志余[2] 包美芳[2] 

机构地区：[1]东南大学附属中大医院神经外科,江苏南京210009 [2]南京航空航天大学生物医学工程系,江苏南京210016

出　　处：《东南大学学报（医学版）》2012年第2期131-135,共5页Journal of Southeast University(Medical Science Edition)

基　　金：国家自然科学基金资助项目(30671997)

摘　　要：目的:近红外光谱(NIRS)技术应用于激光间质热疗大鼠胶质瘤术中实时监测,观察术中NIRS参数变化规律,探讨利用NIRS对胶质瘤激光间质热疗进行实时监测的可行性。方法:将传代培养的C6胶质瘤细胞接种于大鼠左前腋皮下,建立荷瘤大鼠模型,肿瘤生长至直径1～1.5 cm时,在不同时间、功率下对大鼠荷瘤进行808 nm激光间质热疗,观察并记录激光间质热疗时瘤组织的NIRS参数,尤其是优化散射系数(μ's)的变化情况。结果:不同时间、功率下NIRS变化显著。结论:利用NIRS实时活体在位监测激光间质热疗大鼠胶质瘤是可行的。Objective：To explore the feasibility of using near-infrared spectroscopy（NIRS） technology to monitor real-time in laser interstitial thermotherapy for rats with glioma and to observe the process of changes in the optical parameters.Methods：Injecting C6 glioma cells into the left upper limb subcutaneous tissue of rats to establish animal models,when tumor become 1-1.5 cm;Using 808 nm laser irradiate glioma with NIRS monitoring in different time and power;the changes of optical parameters,the reduced scattering coefficient in particular,were observed and recorded by glioma tissue spectroscopy.Results：NIRS changed evidently under different time and power.Conclusion：Real-time use of NIRS technology in laser interstitial thermotherapy for rats with glioma is feasible.

关 键 词：近红外光谱技术 优化散射系数 胶质瘤 激光间质热疗 

分 类 号：R73-354[医药卫生—肿瘤] R730.57[医药卫生—临床医学]