广西巴马长寿人群对氧磷酯酶-1基因多态性分析  

Genetic polymorphisms of PON1 in longevous people in Bama county of Guangxi province

作　　者：梁桂云[1] 覃健[1] 何敏[2] 黎湘娟[1] 施礼威[1] 黄倩倩[1] 黄永全[1] 农清清[1] 张志勇[1] 

机构地区：[1]广西医科大学公共卫生学院职业卫生与环境卫生教研室,广西南宁530021 [2]广西医科大学医学科学实验中心

出　　处：《中国老年学杂志》2012年第7期1338-1340,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助项目(No.30560166;No.81060246);广西科学基金资助项目(桂科自0991115桂科青0832032);广西科学研究与技术开发项目(桂科能0815011-6-5)

摘　　要：目的探讨PON1基因Q192R位点在广西巴马地区不同人群中的频率及PON1基因多态性与巴马地区长寿现象的相关性。方法采用TaqMan探针实时荧光PCR技术对广西巴马长寿地区123例长寿老人(年龄90岁以上,长寿组)以及巴马长寿地区138例无长寿史的健康成年人(年龄24～87岁,对照1组)、巴马非长寿地区147例无长寿史的健康成年人(年龄48～89岁,对照2组)和南丹地区144例无长寿史的健康成年人(年龄21～83岁,对照3组)的PON1基因进行基因分型。结果长寿组与各对照组比较,等位基因和基因型分布差异存在统计学意义(P<0.05)。结论该多态性位点与地域有关,与巴马长寿地区的长寿现象是否有关还需进一步验证。Objective To investigate the correlation between Q192R single nucleotide polymorphisms（SNP） of PON1 gene and hu- man longevity in Bama county. Methods Genotyping of PON1 gene was performed by TaqMan-PCR technique for 123 longevous people （aged 90 - 110, longevity group） from Bama longevity area, 138 healthy cases without long life history from the same area （aged 24 - 87, control group 1 ）, 147 healthy cases without long life history from Bama non-longevity area （aged 48 - 89 ,control group 2） and 143 healthy controls without long life history from Nandan （aged 21-83, control group 3）. Results There were statistically significant change of some frequencies of alleles and genotypes between longevity group and control group 3 （ P 〈 O. 05）. Conclusions These data suggest a modest as- sociation between the PON1 gene Q192R and district. It needs a further research to confirm whether there have any relationship between PON1 gene Q192R and longevity phenomenon in Bama longevity area.

关 键 词：长寿 对氧磷酯酶-1 等位基因 多态性 

分 类 号：R994.6[医药卫生—毒理学]