大脑皮质发育障碍模型病理学与影像学研究  

CharacteriStic of pathology and MRI of rats with DCDs

作　　者：冯占辉[1] 于云莉[1] 楚兰[1] 蔡登华[1] 黄敏[2] 晏勇[2] 

机构地区：[1]贵阳医学院附属医院神经内科,贵州贵阳550004 [2]重庆医科大学附属第一医院神经内科

出　　处：《癫痫与神经电生理学杂志》2012年第2期69-71,77,共4页Journal of Epileptology and Electroneurophysiology(China)

基　　金：国家自然科学基金面上项目（30570636）;贵阳医学院附属医院博士科研启动基金项目

摘　　要：目的：探讨应用X射线构建的大脑皮质发育障碍（DCD）模型鼠病理学与影像学特点。方法：应用直线加速器以175cGy剂量照射孕17dSD母鼠，待仔鼠满56d时行鼠脑磁共振扫描后处死，取脑进行组织病理学研究。结果：DCD仔鼠较对照组大鼠大脑组织重量减轻，体积显著缩小，大脑皮层变薄，厚度较小，双侧侧脑室、第三脑室、第四脑室明显扩大；光镜下见大脑皮层结构紊乱，其内可见结节，海马结构紊乱，海马内结节明显。DCD仔鼠头颅MRI特点：脑体积略小，皮层厚度变薄，双侧侧脑室、第三脑室、第四脑室明显扩大，胼胝体变小伴有缺如，四叠体明显暴露，小脑体积变大。结论：DCD从模型鼠病理学与影像学特征可以反映X射线是构建大脑皮质发育障碍的有效方法，影像学是评估DCD造模是否成功的可供选择的一种手段。Objective：To investigate characteristic of pathology and MRI of rats with DCDs induced by x-ray. Methods：Time-pregnant SD rats were irradiated on embryonic day 17 with 175 cGy or were left untreated. On P56d,on rats were scaned by 1.5Tesla MRI, then were killed and their brains processed for histological studies. Results： The rat offsprings in model group were irritable,mild somnolence, dulless and fewer a ctivities. The model rats with typical pathological features fewer a cluding a thineortical plate, disorder of layer structure, and distinct clusters of neuronal elements that represented heterotopias emerged in cerebralcortex and hippocampus. Brain image feature of the model rat showed that small brain volume,enlargement of both lateral cerebralventricle,the third ventricle and the four ventricle, thinning cortex,thinning corpus callosum and exposure of quadrigeminal bodies. Conclusion： X-ray by which the DCDs mode sare made method; MRI provides a new approach for diagnosis of DCDs.

关 键 词：X射线 皮质发育障碍(DCD) 病理学 磁共振成像(MRI) 

分 类 号：R741.02[医药卫生—神经病学与精神病学]