甘薯叶黄酮对糖尿病小鼠胰腺中MafA蛋白表达影响研究  

The Effects of Flavonoids of Ipomoea batatas Leaves on the Expression of MafA Protein of the Pancreas Tissue in Diabetic Mice

作　　者：李凤林[1,2] 李青旺[2,3] 耿果霞[3] 彭勇[2] 李文烨[3] 冯彩宁[3] 

机构地区：[1]吉林农业科技学院生物工程学院,吉林132101 [2]燕山大学环境与化学工程学院,秦皇岛610400 [3]西北农林科技大学动物科技学院,杨凌712100

出　　处：《食品工业》2012年第4期102-104,共3页The Food Industry

基　　金：河北省秦皇岛市科技发展计划项目(编号D08)

摘　　要：探讨甘薯叶黄酮(FIBL)对糖尿病小鼠糖MafA蛋白表达的影响。采用链脲佐菌素(STZ)诱导Ⅱ型糖尿病(NIDDM)小鼠动物模型,然后将动物分成正常对照组、模型对照组、FIBL低剂量灌胃组、FIBL高剂量灌胃组、罗格列酮灌胃组,药物连续灌胃28 d,检测MafA在糖尿病小鼠胰腺表达量的变化。结果表明小鼠胰腺组织MafA蛋白量增加。甘薯叶黄酮能刺激糖尿病小鼠的MafA基因,使其表达量增加,从而达到降血糖的作用。The effects of flavonoids of Ipomoea batatas leaves （FIBL） on the expression of MafA protein in diabetic mice were studied. After induction of type Ⅱ diabetes mellitus （NIDDM） by streptozotocin （STZ）, the mice were randomly divided into 5 groups： normal control group diabetic control group, low-dose FIBL treated group, high-dose FIBL treated group and Rosiglitazone treated group. After 28 d of treatment with FIBL, the expression of MafA protein of the pancreas tissue in mice were measured. FIBL could stimulate MafA gene of NIDDM mice. increasing the exoression so as to get hypoglvcemic effect.

关 键 词：甘薯叶黄酮 小鼠 糖尿病 MAFA 

分 类 号：R285.5[医药卫生—中药学]