氧头孢中间体的溴代反应研究  

Bromination research of oxacephem intermediate

作　　者：夏小冬[1] 袁红[1] 罗忠枚[1] 叶家林[1] 曹胜华[1] 丁小东[2] 

机构地区：[1]中国医药集团总公司四川抗菌素工业研究所,四川成都610052 [2]四川大学分析测试中心,四川成都610064

出　　处：《化学研究与应用》2012年第4期650-652,共3页Chemical Research and Application

摘　　要：以6-APA(6-氨基青霉烷酸)为原料,经过苯甲酰化保护,硫的氧化,二苯甲酯保护,7位氨基异构化,开环重排,得到异丙烯基表唑啉。用NBS,溴素分别尝试进行溴代,最终得到两个溴代物异构体,并经过核磁共振氢谱对结构进行了确证。Starting from 6-APA （6-aminopenieillanic acid）, the isopropenylepioxazoline was synthesized through five main steps：pro- tection by benzoylation, oxidation of sulfur, protection by diphenylmethyl ester, the iso-mefization of 7-amino group, as well as decy- clization and rearrangement. Two brominated isomers were obtained with the use of NBS and bromine, and their structures were testi- fied by 1H-NMR.

关 键 词：氧头孢中间体 异丙烯基表唑啉 溴代 

分 类 号：O626.2[理学—有机化学]