P16 P53 CyclinD1在卵巢浆液性癌中的表达及意义  

Expression of P16,P53,and CyclinD1 Protein in Low-grade and High-grade Ovarian Serous Carcinoma and Its Clinical Significance

作　　者：赵立武[1,2] 申彦[1] 师宜荃[1] 刘艳[1] 刘易欣[1] 

机构地区：[1]天津医科大学中心妇产临床学院病理科,天津市300100 [2]天津市宁河县医院妇产科

出　　处：《中国肿瘤临床》2012年第7期388-391,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨卵巢高、低级别浆液性癌中P16蛋白、P53蛋白、CvclinDl蛋白的表达情况及意义。方法:应用免疫组化法对45例卵巢浆液性癌(低级别19例,高级别26例)及25例卵巢交界性浆液性囊腺瘤组织进行P16、P53、CvclinD1蛋白检测,并分析其意义。结果:P53在低级别癌中阳性表达率为5%,显著低于高级别癌中的69%(P<0.05),而CyclinD1在低级别癌中阳性表达率为89%,显著高于高级别癌中的15%(P<0.05),P53和CvclinDl表现为负相关(r=0.211)。P16在低、高级别癌肿的阳性表达率分别为84%和92%,高级别癌阳性率高于低级别癌,但差异无统计学意义(P>0.05)。结论:P53和CyclinDl在卵巢高、低级别浆液性癌中的表达有显著差异,对于形态上介于高、低级别之间的浆液性癌,二者可能成为分级的辅助手段。Objective： To investigate the expression of P16, P53, and CyclinD1 protein in low-grade and high-grade ovarian se- rous carcinoma and its clinical significance. The clinical data and pathological findings were analyzed. Methods： Fourty five cases of ovarian serous carcinoma （19 cases of low-grade and 26 cases of high-grade carcinoma） and 25 cases of borderline ovarian serous tu- mors were selected. Immunohistochemical study of P16, P53, and CyclinD1 was performed in all 70 cases. Results： The high-grade se- rous carcinoma had a significantly higher expression level of P53 （ 69% versus 5% ）, while low-grade carcinoma had a significantly higher expression level of CyclinD1 （ 89% versus 15% ）. Significant differences were observed in the expression between P53 and Cy- clinD1. An inverse correlation existed between the expression of P53 and CyclinD1 in tumor grade, r = 0.211. No difference was ob- served in the expression of P16 between low-grade and high-grade ovarian serous carcinoma （ 84% versus 92% ）. Conclusion： P53 over-expression was more frequently detected in high-grade than on low-grade ovarian serous carcinoma. CyclinD1 over-expression was more frequently detected in low-grade ovarian serous carcinomas. Conventional high-grade serous adenocarcinoma is distinct from low-grade serous adenocarcinoma. P 16 over-expression was detected more frequently in ovarian serous carcinoma.

关 键 词：P16 P53 CYCLIND1 卵巢肿瘤浆液性癌 

分 类 号：R737.31[医药卫生—肿瘤]