芬太尼贴联合复方苦参注射液治疗晚期癌痛的疗效观察  

Efficacy Observation of Fentanyl Skin Patches Combined with Compound Sophora flavescens Injection in the Treatment of Cancer Pain

作　　者：豆利华[1] 郭治[2] 

机构地区：[1]邢台市人民医院临床药学室,河北邢台054001 [2]邢台市人民医院肿瘤内科,河北邢台054001

出　　处：《中国药房》2012年第16期1480-1482,共3页China Pharmacy

摘　　要：目的:观察芬太尼贴联合复方苦参注射液治疗晚期癌痛的治疗效果。方法:选取我院收治的晚期癌痛患者62例,随机分为治疗组和对照组,对照组予以芬太尼贴,每贴8.4mg,每72h更换1次;治疗组在对照组用药基础上加用复方苦参注射液15mL加入0.9%氯化钠注射液250mL中静脉滴注,qd,连用12d。观察2组患者的疼痛缓解情况和生存质量(Karnofsky)评分。结果:治疗组的疼痛缓解率和Karnofsky评分均明显优于对照组,2组比较差异有统计学意义(P<0.05)。2组不良反应均较轻微,差异无统计学意义(P>0.05)。结论:芬太尼贴联合复方苦参注射液能有效治疗癌痛,改善晚期癌症患者的生存质量。OBJECTIVE：To study on the therapeutic efficacy of Fentanyl skin patches combined with Compound Sophora flavescens injection in the treatment of cancer pain.METHODS：62 cases suffering from advanced cancer pain which were diagnosed in our hospital were randomly divided into treatment group and control group.Control group was given Fentanyl skin patches 8.4 mg per patch every 72 hours.Treatment group was additionally given Compound S.flavescens injection 15 mL added into normal saline 250 mL with intravenous dripping once a day for consecutive 12 days.RESULTS：The remission rate of treatment group was significantly better than that of control group,there was statistical difference（P0.05）.Karnofsky score of treatment group was significantly better than that of control group,there was statistical difference（P0.05）.There was no significart difference between 2 groups about ADRs（P0.05）.CONCLUSIONS：Fentanyl skin patches combined with Compound S.flavescens injection is effective in the treatment of cancer pain,effectively improve the survival quality among the patients with advanced cancer.

关 键 词：芬太尼贴 复方苦参注射液 癌痛 

分 类 号：R730[医药卫生—肿瘤]