猪皮肤软组织爆炸伤缺损模型的建立及致伤特点观察  

Establishment of a model with explosive soft tissue defects in pig and observation of the injurious characteristics

作　　者：钱玉鑫[1] 芦立轩[1] 侯强[1] 江华[1] 李兵仓[2] 张良潮[2] 刘海[2] 

机构地区：[1]第二军医大学长征医院整形外科,上海200003 [2]第三军医大学大坪医院野战外科研究所六室

出　　处：《中国美容整形外科杂志》2012年第4期248-251,共4页Chinese Journal of Aesthetic and Plastic Surgery

基　　金：全军医药卫生科研项目基金资助（08G069）;南京军区医学科技创新课题（10MA026）;第二军医大学灾害医学专项课题

摘　　要：目的 建立实验室条件下爆炸伤致皮肤软组织缺损的动物模型,观察其致伤特点.方法 选取家猪,采用并排瞬发电雷管作为爆炸物,建立爆炸伤皮肤软组织缺损动物模型.致伤后创面显露,分别于6h、3d、5d、7d进行创面大体、细菌学及病理学检测.结果 并排瞬发电雷管于家猪肩胛、臀部冲击波效应基本一致.致伤后软组织损伤严重,创面面积足够,术后炎症加重,肉芽生长缓慢.创面细菌计数逐渐增加,伤后7d达到1×10^9cfu/g水平.结论 猪软组织爆炸伤缺损模型能真实模拟爆炸伤的致伤效果,致伤面积较大,缺损范围及层次均一,适合作为爆炸伤软组织缺损修复研究的动物模型.Objective To establish an animal model of explosive soft tissue defects under laboratory conditions, on purpose of observing the injurious characteristics. Methods Models of explosive soft tissue defects were established on domestic pigs by using the instantaneous electric detonators. The injurious wounds were exposure and then the gross observation, bacteriological and pathological examinations were performed at 6 hours, 3 days, 5 days and 7 days after injury. Results The blast effects on shoulders and hips were nearly the same. The soft tissue defects were sufficient after explosion, inflammation became more serious and growth of granulation was slow. Bacterial count of wound increased gradually, reaching 1 ×10^9efu/g at 7 days after injury. Conclusion The model with explosive soft tissue defects in pig can simulate the real injurious results by explosion injury with large wound and uniform defective areas and layers, which is suitable for animal experimental studies of soft tissue defects reconstruction.

关 键 词：爆炸伤 软组织 动物模型 

分 类 号：R-332[医药卫生]