同时转移性乳腺癌外科治疗预后因素分析  

Analysis of prognostic factors for synchronous metastatic breast cancer patients treated by surgery

作　　者：秦允生[1] 黄子一[2] 黄楚坚[1] 吴俊东[2] 许强周[1] 

机构地区：[1]汕头大学医学院肿瘤医院胸外科,汕头515031 [2]汕头大学医学院肿瘤医院乳腺科,汕头515031

出　　处：《中华乳腺病杂志（电子版）》2012年第1期14-17,共4页Chinese Journal of Breast Disease(Electronic Edition)

摘　　要：目的探讨影响同时转移性乳腺癌(synchronous metastatic breast cancer,sMBC)外科治疗预后的因素。方法分析2000年1月至2010年12月本院收治sMBC患者269例的临床资料,其中手术治疗40例,非手术治疗229例作为对照组,采用Log-rank检验比较手术治疗组和对照组的生存率差异,Cox回归模型分析相关因素对预后的影响。结果手术组和对照组的1年生存率为83.8%和71.6%(P=0.018),3年生存率为47.1%和23.5%(P=0.000),5年生存率为22.1%和11.4%(P=0.000),差异均有统计学意义。单因素方差分析显示,雌激素受体阳性和术后化疗是提高sMBC患者手术疗效的预后因素,多因素方差分析显示术后化疗是影响手术预后的独立因素。结论部分经过选择的sMBC患者进行外科手术治疗能显著延长生存时间,提高生存率。术后化疗是影响手术效果的重要因素。Objective To explore the prognostic factors of synchronous metastatic breast cancer （sMBC） patients who underwent surgical treatment. Methods The clinical data of 269 sMBC patients admitted into our hospital from January 2000 to December 2010 was collected and analyzed. They included 40 sMBC patients treated by surgery （the surgery group） and 229 sMBC patients receiving non-operative treatment （the control group）. Log-rank test was used to compare the overall survival （OS） of the patients between the surgery group and the control group, and COX regression model to analyze the prognostic factors of surgical treatment. Results The one-year survival of the surgery group and the control group was 83.8% and 71.6% （P = 0. 018） , 3-year survival was 47. 1% and 23.5% （P=0. 000） , 5-year survival was 22. 1% and 11.4% （P= O. 000）. All differences were statistically significant. Univariate analysis showed that estrogen receptor-positive and adjuvant chemotherapy were two important factors in improving the prognosis of surgically treated patients. Multivariate analysis showed that adjuvant chemotherapy is an independent factor affecting surgical outcomes. Conclusion Surgical treatment for selected sMBC patients can significantly prolong survival time and improve survival rate. Adjuvant chemotherapy is an important factor affecting results of operation.

关 键 词：乳腺肿瘤 外科手术 预后 

分 类 号：R737.9[医药卫生—肿瘤]