PDCD5蛋白与雄激素受体在人类前列腺癌组织中表达的相关性研究  

The relation between expression of PDCD5 and androgen receptor in tissue of human prostate cancer

作　　者：丁勇泉[1] 杜跃军[2] 

机构地区：[1]广东省高州市人民医院泌尿外科,高州525200 [2]南方医科大学南方医院泌尿外科

出　　处：《临床泌尿外科杂志》2012年第4期251-254,257,共5页Journal of Clinical Urology

摘　　要：目的:探讨PDCD5蛋白与雄激素受体(AR)在人类前列腺癌(PCa)组织中表达的相关性。方法:用EnVision法对29例PCa组织切片进行PDCD5及AR免疫组化染色,对其在PCa组织中表达的相关性进行统计学分析。结果:依据定性分析结果对PDCD5在AR(+)及AR(-)两组间PCa组织中的表达进行统计学分析显示两者间比较差异无统计学意义(P>0.05),但PDCD5免疫组化染色定量分析提示PDCD5在PCa AR(+)组中表达明显强于AR(-)组(P<0.01)。结论:PDCD5在PCa AR(-)组中的表达要弱于AR(+)组,提示AR缺失可能导致或伴随PCa细胞凋亡的进一步下调,进而引起AIPC/HRPC的发生。Objective：To explore the relationship between PDCD5 and AR expressing in prostate cancer （PCa） tissues. Method ： The expressions of PDCD5 and AR in 29 PCa samples were tested by EnVision immunohisto2 chemical methods. 29 PCa samples were divided into AR（＋） and AR （-） group, the expression of PDCD5 was compared between two groups. Result：According to the qualitative analysis,there was no statistical difference in expression of PDCD5 between AR（＋） and AR（-） PCa tissues（ P〉0.05）, but the statistical outcome of the quantitative analysis showed the intensity of immunohistochemistry staining of PDCD5 in AR（＋） was obviously higher than AR（-） group（ P〈0.01）. Conclusion .. The expression of PDCD5 in PCa with AR（-） was obvious lower than that in PCa with AR（＋）, which suggests deletion of AR may be accompanied with or induce apotosis downregulation and cause AIPC/HRPC.

关 键 词：前列腺癌 PDCD5 雄激素受体 

分 类 号：R737.25[医药卫生—肿瘤]