肝硬化患者血浆血管紧张素Ⅱ与门脉高压的关系及意义  

Clinical Study on the Relationship Between Plasma Angiotensin Ⅱ and Portal Hypertension in Liver Cirrhosis Patients

作　　者：欧文胜[1] 刘展[2] 阳学风[3] 

机构地区：[1]湖南省郴州市第一人民医院消化内科,湖南郴州423000 [2]湖南省人民医院消化内科,湖南长沙410005 [3]南华大学附属南华医院消化内科,湖南衡阳425000

出　　处：《医学临床研究》2012年第3期498-499,共2页Journal of Clinical Research

摘　　要：【目的】探讨肝硬化患者血浆血管紧张素Ⅱ（AT-Ⅱ）水平变化与门脉高压的关系。【方法】用时间分辨荧光免疫分析法测定54例肝硬化患者（其中30例合并腹水）和25例正常人的血浆AT-Ⅱ水平。同时，B超测门静脉宽度，胃镜测食管静脉宽度。【结果】肝硬化患者血浆AT-Ⅱ水平比对照组明显增高，合并腹水患者比无腹水患者增高明显。门静脉和食管静脉宽度随与AT-Ⅱ呈正相关。【结论】肝硬化患者血浆AT-Ⅱ可能在门脉高压形成中起重要作用，AT-Ⅱ与食管静脉曲张的形成有密切关系。[Objective] To explore the relationship between plasma angiotensin Ⅱ（AT-Ⅱ） level and portal hypertension in hepatic cirrhosis patients. [Methods] Time resolved fluoroimmunoassay was used to measure the plasma AT-Ⅱ level in 54 hepatic cirrhosis patients（including 30 patients with ascites） and 25 normal controls. Meanwhile, B-mode ultrasound was used to measure the width of portal vein and gastroscope was used to measure the width of esophagus vein. [Results] Plasma AT-Ⅱ level significantly increased in hepatic cirrhosis patients compared with normal controls, and that in cirrhosis patients complicated with ascites increased more obviously. The width of portal vein and esophagus vein had a positive relation with plasma AT-Ⅱ level. [Conclusion] Plasma AT- Ⅱ level of hepatic cirrhosis patients may play an important role in the genesis of portal hypertension. AT-Ⅱ level has close relation with the genesis of esophageal varices.

关 键 词：肝硬化/血液 血管紧张素Ⅱ/血液 高血压 门静脉 

分 类 号：R575.2[医药卫生—消化系统]