偏头痛患者脑干听觉诱发电位的变化及危险因素  

Changes and risk factors of BAEP in migraines

作　　者：刘彬[1] 沈霞[1,2] 常虹[2,3] 昝坤[1,2] 张尊胜[1,2] 

机构地区：[1]徐州医学院附属医院神经内科,221000 [2]徐州医学院神经病学教研室,221000 [3]徐州医学院附属医院神经电生理室,221000

出　　处：《齐齐哈尔医学院学报》2012年第3期289-290,293,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨偏头痛(migraine)患者脑干听觉诱发电位(brainstem auditory evoked poten-tial,BAEP)的变化及危险因素。方法纳入52例偏头痛患者和50例健康对照者,均行BAEP检查。结果偏头痛患者BAEP异常率为71.15%,左侧Ⅴ波潜伏期(latency period,LP):偏头痛组为(5.65±0.29),对照组为(5.51±0.19),两组间差异有统计学意义(t=2.628,P=0.011);右侧Ⅲ波潜伏期:偏头痛组为(3.77±0.20),对照组为(3.68±0.16),两组间差异有统计学意义(t=2.050,P=0.044);右侧Ⅴ波潜伏期:偏头痛组为(5.67±0.23),对照组为(5.54±0.16),两组间差异有统计学意义(t=2.927,P=0.005);左侧Ⅲ～Ⅴ峰间期(interpeak latency,IPL):偏头痛组为(1.90±0.22),对照组为(1.78±0.21),两组间差异有统计学意义(t=2.354,P=0.021);右侧Ⅰ～Ⅲ峰间期:偏头痛组为(2.14±0.19),对照组为(2.03±0.12),两组间差异有统计学意义(t=2.502,P=0.014);右侧Ⅰ～Ⅴ峰间期:偏头痛组为(4.06±0.36),对照组为(3.89±0.16),两组间差异有统计学意义(t=2.206,P=0.030)。二分类logistic回归分析显示,性别[优势比(odds ratio,OR)=0.078,95%可信区间(confidence inter-val,CI)0.009-0.697;P=0.022],持续时间[优势比(odds ratio,OR)=1.121,95%可信区间(confi-dence interval,CI)0.991-1.191;P=0.041]与BAEP独立相关。结论偏头痛患者急性发作期脑干某些区域存在神经电生理改变,性别及头痛持续时间是其独立危险因素。Objective To investigate the changes of brainstem auditory evoked potential（BAEP） and risk factors in migraines during attack.Methods 52 migraines and 50 controls were chosen.All were then examined by BAEP.Results 71.15% of migraines with abnormal BAEP.The significant prolongation of III and V wave latencies of BAEP was found in migraine patients only.Left V wave latency of migraines was 5.65±0.29 and control was 5.51±0.19（t=2.628,P=0.011）;right III wave latency of migraines was 3.77±0.20 and control was 3.68±0.16（t=2.050,P=0.044）;right V wave latency of migraines was 5.67±0.23 and control was 5.54±0.16（t=2.927,P=0.005）.The significant prolongation of Ⅲ-Ⅴ,Ⅰ-Ⅲ and Ⅰ-Ⅴ interpeak latencies of BAEP was found in migraine patients only.Left Ⅲ-Ⅴ wave interpeak latency of migraines was 1.90±0.22 and control was 1.78±0.21（t=2.354,P=0.021）;right Ⅰ-Ⅲ wave interpeak latency of migraines was 2.14±0.19 and control was 2.03±0.12（t=2.502,P=0.014）;right Ⅰ-Ⅴ wave interpeak latency of migraines was 4.06±0.36 and control was 3.89±0.16（t=2.206,P=0.030）.Binary logistic analysis showed that the gender（odds ratio = 0.078,95% confidence interval 0.009-0.697;P=0.022） and duration（odds ratio = 1.121,95% confidence interval 0.991-1.191;P=0.041） were independently correlated with BAEP.Conclusions Neurophysiological changes of certain areas of the brainstem were found in migrainers during attack,which were independently correlated with gender and duration.

关 键 词：偏头痛 诱发电位 脑干 持续时间 性别 

分 类 号：R741.044[医药卫生—神经病学与精神病学]