肝细胞癌患者外周血循环DNA检测研究进展  

Research progress on peripheral blood circulating DNA detection for hepatocellular carcinoma S

作　　者：邵杰(综述)[1] 华海清(审校) 

机构地区：[1]南京中医药大学第一临床医学院中西医结合临床系,210029 [2]解放军第八一医院全军肿瘤中心肿瘤内科华海清

出　　处：《肿瘤研究与临床》2012年第3期205-208,共4页Cancer Research and Clinic

基　　金：南京军区重点课题（092012）

摘　　要：外周血循环DNA是指存在于血浆或血清中的胞外游离DNA。研究表明恶性肿瘤患者外周血循环DNA明显高于健康者，其表达水平及基因的改变与肿瘤的发生、发展及预后密切相关。检测外周血循环DNA对恶性肿瘤的早期诊断、疗效监测以及预后评估具有重要价值。就近年来肝细胞癌（HCC）患者外周血循环DNA检测研究进展作一综述。Peripheral blood DNA is a kind of extracellular free DNA that existing in plasma or serum. Many researchers have already found that circulating DNA level of cancer patients is significantly higher than that of healthy individuals. The alteration in peripheral blood DNA level and gene expression are closely associated with the occurrence, development and prognosis of cancer. Therefore, it is valuable to detect peripheral blood DNA expression for early diagnosis, therapeutic monitoring and prognosis. This article reviews recent advanced progress in research on peripheral blood DNA detection for hepatocellular carcinoma （ncc）.

关 键 词：癌 肝细胞 早期诊断 DNA 治疗结果 预后 

分 类 号：R73-37[医药卫生—肿瘤]