井穴放血和薏苡仁对脑缺血大鼠脑水肿影响的实验研究  

Influences of Blood-Letting Puncture at Jing-point and Semen Coicis (Yiyiren) on the Brain Edema in Experimental Cerebral Ischemic Rats

作　　者：高靓[1] 杜元灏[2] 李中正[1] 田力欣[1] 郭义[1] 

机构地区：[1]天津中医药大学,天津300193 [2]天津中医药大学第一附属医院,天津300193

出　　处：《针灸临床杂志》2012年第3期49-52,共4页Journal of Clinical Acupuncture and Moxibustion

基　　金：日本国文部省高新技术资助项目;编号:文高助第343;浙江省"重中之重"学科(针灸推拿学)开放基金重点项目;编号:ZTK2010A07

摘　　要：目的:观察井穴放血和静脉注射薏苡仁提取液对大脑中动脉栓塞大鼠局灶性脑缺血损伤后存活率、存活时间及脑水肿的影响,并比较两种疗法单用与联合使用的效果。方法:选用雄性SD大鼠,随机分为正常组、假手术组、模型组和3个治疗组:井穴放血组、薏苡仁组及井穴放血加薏苡仁组。用Longa法建立大脑中动脉栓塞模型后分别进行不同的干预,测定48 h后各组大鼠的脑含水量和脑系数,同时统计各组大鼠的存活率及存活时间。结果:井穴放血和中药薏苡仁提取液静脉注射后,大鼠48 h内的存活时间延长,病变侧的脑含水量、脑系数降低,两法同用效果优于单用。结论:井穴放血和薏苡仁有提高脑缺血大鼠48 h存活率的趋势,可延长脑缺血大鼠48 h存活时间,对缺血性脑水肿有一定的改善作用。Objective：To observe the influences of blood-letting puncture at Jing-point and Semen coicis（Yiyiren） on the survival rate,survival time and brain edema in experimental cerebral ischemic rats.Methods：Healthy male SD rats were selected,and then were randomly divided into normal group,sham operation group,model group and three treatment groups,and they were： the group of bloodletting puncture at Jing（Well）-point,Semen coicis（Yiyiren） group and the group of bloodletting puncture at Jing（Well）-point plus Semen coicis.Middle cerebral artery occlusion（MCAO） models were established according to Longa method.The brains were taken at 48 hours after establishing the model,and the brain water content and brain coefficient were measured.The survival rate of rats in each group and the survival time of the dead rats were calculated.Results：After blood-letting puncture at Jing-point and Semen coicis（Yiyiren）,the survival time of rats that died within 48 hours after cerebral ischemia had been prolonged,the brain water content and coefficient value had been reduced.The combining use of bloodletting puncture at Jing（Well）-point and Semen coicis had better effects.Conclusion：Blood-letting puncture at Jing-point and Semen coicis（Yiyiren） have the tendency of promoting the survival rate of rats after cerebral ischemia in 48 hours and have certain effect of prolonging the survival time of rats that die within 48 hours after cerebral ischemia,and had certain improving function on ischemic brain edema.

关 键 词：井穴放血 薏苡仁 脑缺血 脑水肿 存活时间 

分 类 号：R246.6[医药卫生—针灸推拿学]