可溶性白细胞介素2受体／血清铁蛋白对诊断淋巴瘤相关性噬血细胞综合征的意义  

Significance of serum CD25/serum ferritin in the diagnosis of lymphoma-associated hemophagocyticsyndrome

作　　者：吴道香[1] 王昭[1] 王晓琳[1] 林榕榕[1] 刘暖[1] 张嘉[1] 

机构地区：[1]首都医科大学附属北京友谊医院血液科,北京100050

出　　处：《白血病．淋巴瘤》2012年第3期145-148,共4页Journal of Leukemia & Lymphoma

基　　金：首都医学发展科研基金（2009-10312）;北京市科技计划首都临床特色应用研究（D101100050010005）;中华医学会关于临床医学科研专项资金（11010020246）

摘　　要：目的探讨可溶性白细胞介素2受体（sCD。）／血清铁蛋白在诊断淋巴瘤相关性噬血细胞综合征（LAHS）中的意义，为进一步提高LAHS诊断率，及时诊断和治疗LAHS提供临床依据。方法收集2008年10月至2011年6月首都医科大学附属北京友谊医院经诊的确诊噬血细胞综合征患者70例，包括31例LAHS和39例非LAHS。收集所有患者血清，采用酶联免疫吸附法（ELISA）检测其sCD25水平，并于当日检测血清铁蛋白水平，然后计算sCD25和血清铁蛋白的比值，并比较LAHS和非LAHS之间血清sCD25、血清铁蛋白以及sCD。／血清铁蛋白有无差异。结果LAH：S和非LAHS患者sCD25质量浓度分别为（15760．52±7851．74）、（12727．41±11285．28）pg／ml（t=-1．78，P=0．075，血清铁蛋白中位质量浓度分别为1750．00、2947．00ng／ml（Z=-1．490，P=0．136），sCD25／血清铁蛋白中位比值分别为8．57×10^-3、2．84×10^-3，差异具有统计学意义（Z=-2．106，P=0．035）。结论sCD25／血清铁蛋白在LAHS中明显升高，对诊断LAHS具有重要的提示意义，有可能成为诊断LAHS的重要指标。Objective To investigate the significance of serum CD25 / serum ferritin in the diagnosis of lymphoma-associated hemophagocytic syndrome （LAHS） , so as to provide the clinical basis for improving its recognition and giving effective therapy. Methods The serums were collected from 70 patients with hemophagocytic syndrom in Beijing Friendship Hospital, Capital Medical University during the perio：l from October 2008 to June 2011, including 31 LAHS cases and 39 other disease-associated HPS cases. The serumCD25 level in HPS patients was measured with enzyme-linked immunosorbent assay （ELISA）, and the serum ferritin was measured on the same day. Then the serum CD25/ferritin ratio was calculated and the differences of the serum CD~, serum ferritin and serum CD25/territin ratio between two groups were compared. Results The variance of serum CD25 [（15760.52±7851.74） Pg/ml vs （12727.41 ±11285.28） pg/ml,t=-l.78,P=0.075] and serum ferritin levels （1750.00 ng/ml vs 2947.01） ng/ml, Z=-l.490,P=0.136）were not statistically significant between two groups,while the serum CD25/serum ferritin ratio in LAHS patients was significantly higher than the other group（8.57×10^-3 vs 2.84×10^-3, Z=-2.106, P=0.035）. Conclusion The serum CD25/serum ferritin ratio is statistically higher in LAHS patients, which might be a novel useful marker for predicting underlying malignant lymphoma in HPS patients.

关 键 词：淋巴组织细胞增多症 噬血细胞性 sCD25 铁蛋白质量 酶联免疫吸附测定 

分 类 号：R733.1[医药卫生—肿瘤]