脑梗死患者与其子女血清脂蛋白(α)的相关性研究  

A correlative study on serum lipoprotein(α) in patients of cerebral infarction with that in their children

作　　者：李春盛[1] 李彩[1] 李爱民[1] 周荣斌[1] 高秀兰[1] 

机构地区：[1]北京军区总医院,北京100700

出　　处：《中国危重病急救医学》2000年第5期296-299,共4页Chinese Critical Care Medicine

摘　　要：目的 :探讨有脑血管病家族史的脑梗死患者与其子女血清脂蛋白 (α)浓度的相关性及临床意义 .方法 :检测有明确脑血管病家族史的 2 16例脑梗死患者及其子女的血清脂蛋白 (α)浓度 ,并与 46例正常人及其子女血清脂蛋白 (α)的浓度进行比较。结果 :正常对照组亲、子代以及脑梗死患者亲、子代血清脂蛋白 (α)的相关系数 (r)均为 0 .6 8,P均 <0 .0 0 0 1,显示二者均具有非常显著的相关性。与正常对照组亲、子代相比 ,脑梗死组亲、子代血清脂蛋白 (α)浓度〔分别为 (5 5 0 .0± 341.1) mg/L和 (4 2 2 .9± 30 4.2 ) mg/L〕均显著高于正常对照组亲、子代〔分别为 (2 15 .9± 135 .7) mg/L 和 (144 .6± 10 6 .9) mg/L,P均 <0 .0 0 0 1〕。脑梗死合并糖尿病和高血压者与单纯脑梗死相比 ,其血清脂蛋白 (α)浓度无显著差异 (P均 >0 .0 5 ) ,但脑梗死合并冠心病者其血清脂蛋白 (α)浓度比脑梗死不伴冠心病者显著升高〔分别为 (5 84.7± 345 .3) m g/L 和 (4 6 5 .6± 32 1.4) mg/L,P<0 .0 1〕。结论 :血清脂蛋白 (α)浓度具有显著的遗传特性 ,是脑梗死患者的独立危险因素之一 ,其血清浓度代表动脉粥样硬化的严重程度 ,有脑血管病家族史患者的子女检测血清脂蛋白 (α)浓度 。Objective:To determine serum lipoprotein(α)〔Lp(α)〕 level in patients with cerebral infarction(CI) and definite family history of the disease and their children,and investigate the correlation of the level in parents with that in filial generation and its clinical significance.Methods:Serum Lp(α) level was measured in 216 patients with CI and definite family history of cerebral vascular diseases and their children to compare with that in 46 normal control subjects and their children.Results:The correlation coefficient of Lp(α) in normal persons with that in their children and in the patients with CI with that in their children was 0 68 (both P <0 000 1),showing significant correlation in both situations.In comparison of normal control subjects and their children,serum Lp(α) levels in the patients with CI and their children were significantly higher 〔(550 0±341 1)mg/L vs. (215 9±135 7)mg/L;(422 9±304 2)mg/L vs.(144 6±106 9)mg/L,respectively,both P <0 000 1〕.The serum Lp(a) concentration in persons with CI accompanied by diabetes mellitus(DM) and hypertension was not significantly different from that in simple CI patients (both P >0 05).However,the serum Lp(α) concentration in cases with CI accompanied by coronary arterial diseases (CAD) was significantly different from that in the cases without CAD 〔(584 7±345 3)mg/L vs.(465 6±321 4)mg/L, P <0 01〕.Conclusions:We conclude that serum Lp(α) level is genetic,and it is an independent risk factor for CI.Its concentration indicates the severity of atherosclerosis.The serum Lp(α) level in the children of patients with definite family history of cerebral vascular disease is of important significance in the prediction of cerebral infarction.

关 键 词：血清脂蛋白(Α) 脑梗死 亲代 子代 

分 类 号：R743.33[医药卫生—神经病学与精神病学]