One Pot Synthesis of Medicinally Important cis-2.Methyl-4-am i no s u bstituted-1,2,3,4-tetrahyd roq u i nolines  

作　　者：Kiran,Kumar H.C Mahadevan,K.M Prabhakara,VarmaP Srinivasa,A 

机构地区：[1]Department of Post Graduate Studies and Research in Chemistry,School of Chemical Sciences,Kuvempu Univesity,Shankaraghatta-577451,Karnataka,India [2]Bioorganics andApplied Materials Pvt.Ltd.,PIA,Bangalore-58,Karnataka,India [3]Cdymax(India)Pharma Pvt.Ltd.116/117,KIADB Industrial Area,Jigani,Bangalore-560105,Karnataka,India

出　　处：《Chinese Journal of Chemistry》2012年第3期534-540,共7页中国化学（英文版）

摘　　要：A simple synthesis of medicinally important cis-2-methyl-4-azapan-2-one-1,2,3,4-tetrahydroquinolines/cis-9- （2-methyl-l,2,3,4-tetrahydroquinolin-4-yl）-9H-carbazole was reported. Multicomponent one pot synthesis with ani- lines and N-vinylcaprolactam/N-vinyl carbazole via imino Diels-Alder reaction by using antimony trichloride as catalyst and acetonitrile as solvent was employed. NMR technique （2D） was used to study the regio- and stereo- chemistry of newly synthesized compounds. The cis diastereo-selectivity of the products was predicted by COSY and NOESY studies.A simple synthesis of medicinally important cis-2-methyl-4-azapan-2-one-1,2,3,4-tetrahydroquinolines/cis-9- （2-methyl-l,2,3,4-tetrahydroquinolin-4-yl）-9H-carbazole was reported. Multicomponent one pot synthesis with ani- lines and N-vinylcaprolactam/N-vinyl carbazole via imino Diels-Alder reaction by using antimony trichloride as catalyst and acetonitrile as solvent was employed. NMR technique （2D） was used to study the regio- and stereo- chemistry of newly synthesized compounds. The cis diastereo-selectivity of the products was predicted by COSY and NOESY studies.

关 键 词：imino Diels-Alder antimony trichloride TETRAHYDROQUINOLINE N-VINYLCAPROLACTAM N-VINYLCARBAZOLE 

分 类 号：O621.25[理学—有机化学] TQ457.29[理学—化学]