癫痫患者发作间歇期人格改变及相关因素分析  

lnterictal personality change and its related factors in epilepsy patients

作　　者：毛玲艳[1] 丁晶[1] 彭伟锋[1] 张宇浩[1] 马昱[1] 范薇[1] 汪昕[1] 

机构地区：[1]复旦大学附属中山医院神经内科,上海200032

出　　处：《中华神经科杂志》2012年第4期224-228,共5页Chinese Journal of Neurology

摘　　要：目的探讨癫痫患者发作间歇期人格改变的特点及影响因素。方法选取诊断为原发性或隐源性癫痫患者115例（癫痫组）及年龄、性别匹配的健康对照42名（对照组）。所有入组者均经简易精神状态检查以及简明精神量表分析并确认认知功能及精神状态正常。采用艾森克人格问卷成人版对发作间歇期的癫痫患者及对照组进行人格评估，用计算机后处理软件分别获取外向质（E分）、精神质（P分）、神经质（N分）以及掩饰性（L分）的数值，并进行统计学分析。使用Pearson相关分析及Logistic多因素回归分析对患者艾森克人格问卷评分与可能的影响因素进行分析。结果癫痫组患者的P分（50．48±9．55）和N分（51．13±12．89）均较对照组（P分：46．59±7．28，N分：46．83±9．40）明显升高（t=2．374、2．266，均P〈0．05），E分（51．74±10．74）较对照组（60．37±9．84）显著降低（t=-4．511，P〈0．01）。两组间L分无明显差异。多因素分析显示：癫痫病程与P分独立相关（／3=0．043，P〈0．05），受教育年限与E分独立相关（口=0．109，P〈0．05），而癫痫患者年龄、性别、起病年龄、发作频率、发作类型、国立医院癫痫严重程度量表评分、服用抗癫痫药物种类、癫痫家族史、癫痫持续状态史与各项人格评分均无明显相关性。结论癫痫患者发作间歇期存在人格改变，主要表现为精神质和神经质评分增高，外向质评分减低。精神质人格与癫痫病程独立相关，外向质人格与癫痫患者受教育程度独市相关。Objective To explore the personality change in patients with epilepsy during the interictal period and the correlation between clinical features and personality change. Methods One hundred and fifteen patients with idiopathic or eryptogenic epilepsy were chosen as the epileptic group and 42 age- and sex-matched healthy subjects served as controls. All participants were evaluated by Mini Mental Status Examination and Brief Psychiatric Rating Scale to ensure the normality of cognition and mental state. Personality was evaluated by adult version of Eysenck Personality Questionnaire （EPQ） in interietal epilepsy patients and healthy controls. Scores of psychoticism （ P）, extraversion （E）, neuroticism （N） and lie （L） were obtained using computer software. Pearson correlation analysis and logistic regression were used to investigate the scores of EPQ and influential factors. Results P and N scores were significantly elevated in epilepsy patients compared with controls （ P scores： 50.48 ±9.55 vs 46.59± 7.28, N scores ： 51.13 ±12.89 vs 46. 83± 9.40 ; t = 2. 374, 2. 266, both P 〈 0. 05 ） , while E scores were significantly decreased （51.74±10. 74 vs 60. 37 ± 9.84 ; t = - 4. 511, P 〈 0. 01 ）. There were no significant differences in L scores. Multivariate analysis showed that disease duration was independently correlated to P scores （/3 = 0. 043,P 〈0. 05）, while education was correlated to E scores （/3 = 0. 109,P 〈 0. 05）. There were no significant correlations between personality scores, patient age, gender, age of onset, frequency, seizure type, National Hospital Seizure Severity Scale scores, family history, history of status epilepticus and anti- epileptic drugs usage. Conclusions High psychoticism and neurotieism and low extraversion scores are correlated to patients with epilepsy during the interictal period. Disease duration is an independent risk factor for psyehoticism personality, and education level is an independent risk factor for extraversion personality in

关 键 词：癫痫 人格障碍 问卷调查 

分 类 号：R742.1[医药卫生—神经病学与精神病学]