子宫内膜癌中MUC1和E-cad的表达及其相关性  

Expression of MUC1 and E-cadherin and their relationship in endometrial carcinomas

作　　者：赵时梅[1] 韦毓 罗宇[1] 史琳[1] 任传伟[1] 

机构地区：[1]柳州医学高等专科学校,广西柳州545005 [2]柳州市妇幼保健院,广西柳州545001

出　　处：《现代肿瘤医学》2012年第4期675-679,共5页Journal of Modern Oncology

基　　金：广西壮族自治区教育厅科研项目(编号:200911MS285)

摘　　要：目的:探讨MUC1和E-cad在子宫内膜样腺癌组织中的表达及其相关性。方法:采用免疫组化En-Vision法检测30例增生期子宫内膜组织、36例单纯性增生内膜、50例不典型增生内膜及55例子宫内膜样腺癌组织中MUC1和E-cad蛋白表达。结果:从增生期子宫内膜→宫内膜单纯性增生→宫内膜不典型增生→子宫内膜样腺癌,MUC1和E-cad的正常表达率逐渐降低,异质表达率逐渐升高(P=0.000)。MUC1和E-cad蛋白表达在子宫内膜样腺癌组织中呈正相关关系(r=0.290,P=0.032)。结论:MUC1和E-cad蛋白异质表达可能与子宫内膜样腺癌的发生有关。MUC1和E-cad在子宫内膜样腺癌的形成过程中可能具有协同作用。Objective：To investigate the relationship of expression of MUC1 and E-cad protein in the pathologenesis of endometrial adenocarcinoma.Methods： The expression levels of MUC1 and E-cad protein in endometrial adenocarcinomas（n=55）,endometrial atypical hyperplasia（n=50）,endometrial hyperplasia（n=36） and normal proliferative endometrium（n=30） were examined by immunohistochemistry（EnVision method）.Results： The positive rates of both MUC1 and E-cad protein were gradually reduced in normal proliferative endometrium,endometrial hyperplasia,endometrial atypical hyperplasia and endometrial adenocarcinoma（P=0.000）.The expression of MUC1 protein was positive related to that of E-cad in endometrial adenocarcinoma（P=0.032）.Conclusion： The high unconventionality expression of MUC1 and E-cad might be related with the formation of endometrial adenocarcinoma,which reveals that they may be co-act in the occurrence and development of endometrial adenocarcinoma.

关 键 词：子宫肿瘤 腺癌 黏液素1 上皮钙黏附蛋白E 

分 类 号：R737.33[医药卫生—肿瘤]