定量分析碘染后色变数据诊断早期食管癌的初探  

Quantitative analysis of the color change of iodine staining for diagnosis of early esophageal cancer

作　　者：叶武[1] 刘鹏飞[1] 曹向明[2] 沈卫东[1] 陆小峰[3] 钱建忠[4] 徐娟[1] 

机构地区：[1]东南大学附属江阴医院消化内科,江苏江阴214400 [2]东南大学附属江阴医院肿瘤科,江苏江阴214400 [3]上海大学信息工程系 [4]东南大学附属江阴医院病理科,江苏江阴214400

出　　处：《中华消化内镜杂志》2012年第4期208-210,共3页Chinese Journal of Digestive Endoscopy

摘　　要：目的初步探讨计算机定量分析食管黏膜碘染色后的色变数据诊断早期食管癌的价值。方法应用Lugol碘液对58例患者食管的可疑病灶进行染色，采集图像，进行病理活检，应用计算机的颜色定量分析软件对黏膜颜色变化进行定量分析，并与病理结果进行比较。结果58例患者共发现62个异常染色灶，其中黏膜组织慢性炎症19个，低级别上皮内瘤变13个，高级别上皮内瘤变11个，鳞状细胞癌19个。颜色分量参数R／R’（红色）及H／H’（色调）在上述4组不同的病理改变间有统计学意义（P〈0．05）。结论计算机定量分析食管黏膜碘染色后的色变数据，能较好地反映病灶的病理性质，帮助提高活检的准确性并有望提高食管早期癌的诊断率。Objective To investigate the diagnostic value of quantitative analysis of the color change of iodine staining for early esophageal cancer. Methods A total of 58 patients with suspected esophageal diseases were recruited to this study. The lesions were stained with lugols iodine, and biopsies were performed. Quantitative analysis of color change under endoscopy was also performed by analysis software and the results were compared with pathological findings. Results A total of 62 iodine-unstained lesions in 58 patients were found, including 19 chronic inflammation, 13 low-grade intraepithelial neoplasia, 11 highgrade intraepithelial neoplasia and 19 squamous cell cancer. The color parameters of R/R＇ （red） and H/H＇ （hue） were significantly different among the four groups （ P 〈 0. 05 ）. Conclusion Computerized chro- moendoscopy is helpful in determining pathological characteristics of esophageal lesions, thereby improving the accuracy of endoscopic biopsy and the diagnosis rate of early esophageal cancer.

关 键 词：食管癌 早期诊断 内窥镜检查 色变 定量分析 

分 类 号：R735.1[医药卫生—肿瘤]