SHP-1和SHP-2在鼻咽癌组织中的表达及其临床意义  

Expression of SHP-1 and SHP-2 in Human Nasopharyngeal Carcinoma Tissues and Their Clinical Significance

作　　者：彭纲[1] 曹如波[1] 李跃华[1] 黄晶[1] 丁乾[1] 伍钢[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院肿瘤中心,武汉430022

出　　处：《肿瘤防治研究》2012年第4期421-424,共4页Cancer Research on Prevention and Treatment

摘　　要：目的探讨SHP-1和SHP-2在鼻咽癌组织中的表达及其与临床病理特征的关系。方法采用免疫组织化学方法检测53例鼻咽癌组织和21例正常鼻咽组织中SHP-1、SHP-2蛋白的表达,分析他们与各临床病理特征之间的关系。结果鼻咽癌组SHP-1表达率(64.2%)明显高于对照组(28.6%)(P<0.01)。SHP-1蛋白高表达与淋巴结转移、分期、组织学类型有关,与性别、年龄无关。SHP-2在鼻咽癌及正常鼻咽组织中表达无差异。结论 SHP-1的异常高表达可能参与鼻咽癌的发生、发展,SHP-1可作为鼻咽癌转移的预测指标。Objective To investigate the expression of SHP-1 and SHP-2 protein in nasopharyngeal carcinoma and their relationship with clinical characteristics.Methods Immunohistochemistry was used to detect the SHP-1 and SHP-2 protein in 53 patients with nasopharyngeal carcinoma（NPC） and 21 normal nasopharyngeal tissues.At the same time,the relationship between SHP-1 and SHP-2 and clinicopathological factors were analyzed.Results The rate of positive expression of SHP-1 was significantly higher in nasopharyngeal carcinoma tissues than that in normal nasopharyngeal tissues（64.2% vs.28.6%,P〈0.01）.The expression rate of SHP-2 in NPC was 30.2%,while that in normal nasopharyngeal tissues was 33.3%.There was no statistic significance（P〉0.05）.The expression of SHP-1 in NPC tissues was correlated with differentiation,lymph node metastasis,T stage and clinical stage,but didn′t relate to gender and age.Conclusion SHP-1 may participate in the development and progression of nasopharyngeal carcinoma,and may be used to predict the metastasis of nasopharyngeal carcinoma.

关 键 词：SHP-1 SHP-2 鼻咽癌 免疫组织化学 转移 

分 类 号：R739.63[医药卫生—肿瘤] R730.2[医药卫生—临床医学]