rCBV变化与VEGF表达对胶质母细胞瘤术后放疗病人生存期的预测研究  

Predictive study of rCBV change and VEGF expression for survival time of glioblastoma patients treated by postoperative radiotherapy

作　　者：陈谦[1,2] 曲金荣[3] 陈绪珠[1] 王永志[4] 张伟[4] 艾林[1,2] 李少武[1,2] 戴建平[1,2] 江涛[4] 

机构地区：[1]首都医科大学附属北京天坛医院放射科,100050 [2]北京市神经外科研究所神经影像中心 [3]河南省肿瘤医院放射科,郑州450008 [4]北京市神经外科研究所神经外科

出　　处：《中国微侵袭神经外科杂志》2012年第4期160-163,共4页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：国家重点基础研究发展计划(编号:2011CB 707804);河南省科技厅国际合作项目(编号:114300510016)

摘　　要：目的探讨相对脑血容量(relative cerebral blood volume,rCBV)变化和血管内皮生长因子(vascular endothelialgrowth factor,VEGF)表达对胶质母细胞瘤全切手术后辅助放射治疗病人的无进展生存期(PFS)和总生存期(OS)的预测作用。方法回顾性分析16例外科全切术后辅助放射治疗的胶质母细胞瘤病人的临床资料。在放射治疗前和放射治疗中(累计放射剂量为30 Gy)各进行1次灌注成像检查,计算rCBV值。免疫组化检测VEGF表达。采用Kaplan-Meier生存曲线分析PFS和OS。结果不同年龄、VEGF表达和rCBV变化的病人,其在PFS的差异具有统计学意义(均P<0.05)。仅有VEGF表达不同的病人在OS的差异具有统计学意义(P<0.05)。结论 VEGF表达和rCBV变化可以作为判定胶质母细胞瘤PFS的预测物。同时,VEGF表达可以作为判定胶质母细胞瘤OS的预测物。Objective To analyze the predictive effects of change of relative cerebral blood volume（rCBV） and expression of vascular endothelial growth factor（VEGF） on progression free survival（PFS） and overall survival（OS） in glioblastoma patients treated by total resection assisted with postoperative radiotherapy.Methods Clinical data of 16 glioblastoma patients treated by total resection assisted with postoperative radiotherapy were analyzed retrospectively.The dynamic susceptibility contrast-enhanced perfusion MR imaging was performed to calculate the rCBV before and during radiotherapy（the total radiation dose,30 Gy）.The expression of VEGF was detected by immunohistochemistry.PFS and OS were analyzed by Kaplan-Meier survival curves.Results There were significant differences in PFS between patients with different ages,VEGF expressions and rCBV changes（all P 0.05）.There was obvious difference in OS between patients with different expressions of VEGF（P 0.05）.Conclusions VEGF expression and rCBV changes can be considered as the predictors of PFS,and VEGF expression can also be a predictor of OS in glioblastoma patients.

关 键 词：胶质母细胞瘤 脑血容量 相对 血管内皮生长因子 放射治疗 灌注成像 

分 类 号：R739.41[医药卫生—肿瘤]