非小细胞肺癌“寡转移”的概念及治疗策略  

The Conceptual Oligometastatic Non-small Cell Lung Cancer and Therapeutic Strategies

作　　者：康晓征[1] 陈克能[1] 

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所胸一科,恶性肿瘤发病机制及转化研究教育部重点实验室

出　　处：《中国肺癌杂志》2012年第4期242-245,共4页Chinese Journal of Lung Cancer

基　　金：国家重点基础研究发展计划(973计划)(No.2011CB504300);国家自然科学基金(No.30572130);北京市自然科学基金(No.7102029);首都医学发展科研基金(No.2007-1023);北京市卫生系统高层次卫生技术人才培养计划(No.2009-2-17)资助~~

摘　　要：非小细胞肺癌是发病率及致死率最高的恶性肿瘤之一。约20%-50%会发生远处转移,最常见的转移部位为脑、骨、肝及肾上腺。寡转移状态是一段肿瘤生物侵袭性较温和的时期,存在于局限性原发灶与广泛性转移之间的过渡阶段,转移瘤数目有限并且转移器官具有特异性。"寡转移"来源于微转移,肿瘤细胞已具有器官特异性,但尚不具备全身播散的遗传倾向。治疗寡转移状态的关键是局部控制,需要兼顾预防远处转移、治疗隐匿性转移灶、治疗寡转移灶和全身治疗结束后清除残留癌灶四个方面。本文旨在对"寡转移"概念在非小细胞肺癌常见转移脏器治疗中的应用作一综述。Non-small cell lung cancer （NSCLC） ranks among the most prevalent malignancies and is the major cause of cancer-related deaths worldwide. Nearly 20%-50% will accompany by metastatic disease and the most common ex- trapulmonary sites of distant metastases are the brain, bone, liver and adrenal gland. The oligometastatic state is a biologically mild tumor stage and a intermediate state in which spread may be limited to specific organs and metastases might be present in limited numbers. Oligometastases are thought to arise from micrometastases, which have been dormant for a period of time. Local control may be an crucial component of a curative therapeutic strategy in the following four clinical schemes： to prohibit metastases; to cure occult metastatic disease; to remedy oligometastases; and to deracinate any residual lesion after systemic therapy. This review aims to outline the concept of the oligometastatic NSCLC and its strategies of treatment.

关 键 词：肺肿瘤 肿瘤转移 治疗 放疗 

分 类 号：R734.2[医药卫生—肿瘤]