胰岛素样生长因子在UC临床特征评估中的价值  

Value of Insulin-like Growth Factor in Evaluation of Clinical Characteristics in Patients with UC

作　　者：徐亚[1] 陆忠凯[1] 陈志荣[1] 

机构地区：[1]南京医科大学附属苏州医院消化科,215001

出　　处：《胃肠病学》2012年第3期161-163,共3页Chinese Journal of Gastroenterology

摘　　要：背景:溃疡性结肠炎(UC)临床诊治有时较为困难,目前尚缺乏可反映本病临床特征的特异性生物学指标。目的:探讨胰岛素样生长因子(IGF)在评估UC临床特征中的价值。方法:采用酶标化学发光免疫分析法检测124例UC患者和50例健康对照者的外周血IGF-Ⅰ和胰岛素样生长因子结合蛋白3(IGFBP3)的表达,并探讨两者与UC病情严重程度、治疗效果和癌变的相关性。结果:UC患者外周血IGF-Ⅰ和IGFBP3水平较正常对照组明显下降,且随病情加重呈进行性下降,以中重度UC为著(P<0.05)。UC治疗有效者IGF-Ⅰ和IGFBP3水平较治疗前明显升高,以中重度UC为著(P<0.05)。UC癌变时IGF-Ⅰ和IGFBP3较正常对照组明显升高(P<0.05)。结论:IGF-Ⅰ和IGFBP3可有助于评估UC的病情严重程度和治疗效果,且在预测UC癌变中有重要价值。Sometimes, the diagnosis and treatment of ulcerative colitis （UC） is quite difficult in clinical practice. So far, there is no specific biomarker for the evaluation of clinical characteristics of UC. Aims： To explore the value of insulin-like growth factor （IGF） in evaluation of clinical characteristics of UC. Methods： In 124 patients with UC and 50 healthy controls, enzyme-labeled chemiluminescent immunometric assay was used for the detection of IGF- I and insulinlike growth factor binding protein （IGFBP） 3 in peripheral blood, and to explore their relationship with clinical characteristics, therapeutic efficacy and carcinogenesis of UC. Results： Levels of IGFI and IGFBP3 in patients with UC were significantly lower than those in healthy controls, and declined progressively with the increase of disease severity, especially in moderate and severe UC group （P〈0.05）. Levels of IGF- I and IGFBP3 increased obviously when UC was treated effectively, especially in moderate and severe UC group （P〈O.05）. IGFI and IGFBP3 levels increased significantly when carcinomatous changes occurred in UC patients. Conclusions： IGFI and IGFBP3 may be useful in evaluation of disease severity and therapeutic efficacy of UC, and have important roles in predicting the carcinogenesis of UC.

关 键 词：胰岛素样生长因子Ⅰ 结肠炎 溃疡性 治疗效果 

分 类 号：R574.62[医药卫生—消化系统]