胆碱酯酶抑制药与痴呆的治疗  

Cholinesterase inhibitors for the treatment of dementia

作　　者：孙洪吉[1] 解恒革[1] 

机构地区：[1]解放军总医院南楼神经内科,北京100853

出　　处：《临床药物治疗杂志》2012年第2期1-6,共6页Clinical Medication Journal

摘　　要：胆碱酯酶抑制药是近20年来治疗痴呆的主要药物。虽然人们一直在开发其他类型的痴呆治疗药物,但是迄今为止仍未取得重大临床突破。目前应用的胆碱酯酶抑制代表药物有多奈哌齐(donepezil)、利斯的明(rivastigmine)、加兰他敏(galantamine)以及石杉碱甲(huperzine A)等。本文主要概述了胆碱酯酶抑制药在阿尔茨海默病、血管性痴呆、路易体痴呆和帕金森病痴呆中的临床研究进展,为临床应用此类药物提供参考。Cholinesterase inhibitor has been the main kind of drugs to treat dementias for almost twenty years. While researchers throughout the world have been developing new kinds of drugs against dementias ,they haven＇t yet achieved significant clinical breakthroughs up to date. And donepezil, rivastigmine, galantamine, as well as huperzine A are the reprentative drugs of cholinesterase inhibitors. By means of analyzing literatures, we summarize the clinical research developments of these four cholinesterase inhibitors＇treatments in Alzheimer＇s disease,Vascular dementia,Dementia with Lewy bodies and Parkinson＇s disease dementia to provide references of their clinical use

关 键 词：胆碱酯酶抑制药 阿尔茨海默病 血管性痴呆 路易体痴呆 帕金森病痴呆 

分 类 号：R743[医药卫生—神经病学与精神病学]