不同性别早发冠心病患者临床危险因素对比分析  

Comparison of risk factors for premature coronary artery disease between males and females

作　　者：鲁明[1] 高炎[1] 王宁夫[1] 李虹[1] 郭士遵[1] 钟益刚[1] 

机构地区：[1]杭州市第一人民医院心内科,310006

出　　处：《浙江医学》2012年第6期446-448,共3页Zhejiang Medical Journal

基　　金：杭州市科技局重点项目（20080333Q03）

摘　　要：目的 比较不同性别早发冠心病（PCAD）患者临床危险因素的差异,并探讨其意义.方法 选取经冠状动脉造影确诊的PCAD患者270例,分为男性组（158例）和女性组（112例）,采集两组患者常见心血管危险因素（高血压、糖尿病、高脂血症、早发冠心病家族史、吸烟、BMI等）和血液指标（血脂、纤维蛋白原、C反应蛋白等）,并作对比分析.结果 两组间高血压、糖尿病、早发冠心病家族史、肥胖、血脂异常的差异均无统计学意义（均P ＞0.05）,男性组吸烟比例显著高于女性组（P＜0.01）,男性组血HDL-C和载脂蛋白a（Apoa）水平显著低于女性组（P＜0.01）.结论 男性吸烟和血脂紊乱比例高于女性,提示吸烟和血脂紊乱是男性PCAD患者发病时间提前的重要危险因素,HDL-C和Apoa水平下降可导致冠状动脉保护机制降低.Objective To compare the sexual differences in risk factors ot patients with premature coronary artery disease （PCAD）. Methods Two hundred and seventy patients with PCAD were diagnosed by coronary angiography, including 158 male patients （〈55y） and 112 female patients （〈65y）. The cardiovascular risk factors including hypertension, diabetes, family history of PCAD, smoking, dyslipidemia, body mass index and blood parameters （blood lipids, fibrinogen, CRP,etc.） were analyzed. Results There were no significant differences in prevalence of hypertension, diabetes, family history, obesity and dyslipidemia （P 〉0.05）; smoking was more prevalent among men than women （73.4% vs 1.8%, P〈0.01）, the blood HDL-C and Apoa levels of the male group were much lower than those of the female group（P〈0.05）. Conclusion Smoking and dyslipidemia are more prevalent amon.q men than women, suggesting these two risk factors may contribute early onset of male patients with PCAD.

关 键 词：早发冠心病 临床危险因素 性别 

分 类 号：R774[医药卫生—眼科]