HLA-DRB1基因多态性与河南汉族人群急性淋巴细胞白血病关联分析  

Association between HLA- DRB1 alleles polymorphism and susceptibility to acute lymphoblastic leukemia in a Henan Chinese population of Han nationality

作　　者：曹孟德[1] 秦东春[2] 岳保红[2] 苏堤[1] 王东升[1] 苏天水[2] 燕桂香[2] 盛光耀[3] 

机构地区：[1]河南医科大学微生物学与免疫学教研室,郑州4500522 [2]河南医科大学第一附属医院检验科,郑州4500523 [3]河南医科大学第一附属医院小儿科,郑州450052

出　　处：《河南医科大学学报》2000年第1期46-48,共3页Journal of Henan Medical University

基　　金：河南省科技攻关基金资助项目! 97120027

摘　　要：目的 :探讨急性淋巴细胞白血病 (ALL)易感性与HLA DRB1基因多态性之间的关联性 ,找出ALL的易感基因。方法 :采用序列特异性引物聚合酶链反应 (PCR SSP)DNA分型技术对 5 6例ALL患者和 10 5例健康对照组进行了HLA DRB1基因分型。结果 :ALL组与HLA DR7基因关联 ,基因频率为 2 4.1% ,RR =2 .5 6 ,χ2 =7.34 ,P <0 .0 1,病因分数为 0 .2 9;其他等位基因频率ALL组与对照组间差异无显著性。结论 :HLAAim: In order to explore the association between HLA DRB1 alleles polymorphism and susceptibility to acute lymphoblastic leukemia in a Henan Chinese population of Han nationality and find the susceptible genes of ALL. Methods: 105 normal people and 56 patients with acute lymphoblastic leukemia (ALL) were carried out HLA DRB1 genotyping analysis by polymerase chain reaction with sequence specific primers (PCR SSP). Results: Compared with normal controls, the frequency of HLA DR7 was significantly increased in the patient group, with a relative risk (RR) being 2.56,χ 2=7.34, P <0.01 and with an etiological fraction (EF) being 0.29, while the frequencies of other DRB1 alleles were not significantly increased in the ALL group. Conclusion: These results were shown that susceptibility to ALL are strongly associated with the HLA DR7 gene.

关 键 词：HLA-DRB1基因 白血病 淋巴细胞 急性 

分 类 号：R733.710.2[医药卫生—肿瘤]