牛磺酸对兔心肌缺血再灌注后血液流变学的影响  

Ameliorative effect of taurine on hemorheologic feature after ischemic neperfused myocardium in rabbits

作　　者：金寒[1] 鄢文海[2] 李灵红 岳鹤声 李永欣[1] 杨莹[1] 汤宁[2] 王柏生[1] 

机构地区：[1]河南医科大学实验中心,郑州4500522 [2]河南医科大学病理生理学教研室,郑州4500523 [3]光山县人民医院,光山465450

出　　处：《河南医科大学学报》2000年第1期49-51,共3页Journal of Henan Medical University

基　　金：河南省科技攻关基金资助项目! 934022000

摘　　要：目的 :在兔心肌缺血再灌注模型上 ,观察牛磺酸对其血液流变学改变的影响。方法 :2 0只兔随机分 2组。 1组 (对照组 ) :心肌缺血 45min ,再灌注 180min ,未给处理 ;2组 (牛磺酸组 ) :再灌注前 5min从耳缘静脉注入牛磺酸 140mg/kg,余同 1组。阻断冠脉前和再灌注 180min时二次取血 ,测定血液流变学指标。结果 :①对照组再灌注后与阻断冠脉前相比 ,高、低切变率下的全血粘度、血浆粘度、红细胞流动系数明显恶化 (P <0 .0 5 ) ;②与对照组相比 ,牛磺酸组再灌注 180min时 ,高、低切变率下的全血粘度、血浆粘度、红细胞流动系数均明显改善 (P <0 .0 5 )。结论 :牛磺酸可显著改善再灌注后的血液流变性 ,保护缺血再灌注损伤心肌。Aim: To investigate the protective effect of taurine on hemorheologic feature,we reproduced the ischemic reperfused myocardium in rabbits. Methods: Twenty rabbits were divided into 2 groups. Group 1(control group): no treatment was given during the 45 min ischemia and 180 min reperfusion. Group 2 (Taurine group): 5 min before reperfusion, taurine was given to rabbits in the bolus of 140 g/kg body weight. The blood samples were taken before ischemia and at the time of reperfusion for 180 min to be insected the fallowing parameters. Rusults: Whole blood viscosity at the high or low sheer was deteriorited significantly( P <0. 05) at the point of reperfusion for 180 min as compared with those before ischemia in control group, but those parameters were ameliorated in Taurin group as compared with those in control group at time of 180 min reperfusion.Condusion: Tourin can improve the hemorheologic condition to protect ischemic reperfusion myocardium.

关 键 词：血液流变学 牛磺酸 再灌注损伤 心肌缺血 

分 类 号：R542.2[医药卫生—心血管疾病] R364.12[医药卫生—内科学]