表皮生长因子受体和转化生长因子-α在前列腺癌表达中的临床意义  

Expression of epidermal growth factor receptor and transforming growth factor-α in prostatic carcinoma

作　　者：严春寅[1] 郭震华[1] 陈卫国[1] 陈赐龄[1] 王晖[2] 张炜[2] 

机构地区：[1]苏州医学院附属第一医院泌尿外科,江苏苏州215006 [2]苏州医学院附属第一医院泌尿外科实验室

出　　处：《临床泌尿外科杂志》2000年第1期28-30,共3页Journal of Clinical Urology

摘　　要：目的 :探讨表皮生长因子受体 (EGFR)和转化生长因子 -α(TGFα)在前列腺癌 (PCa)中表达的临床意义。方法 :采用免疫组化法检测 43例 PCa组织和 5例正常前列腺组织中 EGFR和 TGFα的表达。结果 :正常前列腺组织中 EGFR和 TGFα分别表达在上皮细胞和基质中。 EGFR和 TGFα在 PCa细胞上的共同表达率为5 5 .8% ,二者密切相关 (r =0 .5 19) ,并与 PCa分期有关 (P <0 .0 1) ;此类患者的生存时间明显短于 EGFR和TGFα阴性表达的患者 (P <0 .0 1)。结论 :EGFR和 TGFα形成的自分泌环可能与 PCa恶化和内分泌治疗失败有关 ,同时检测它们可作为判断 PCa临床分期、预后的一个重要指标。Purpose: To evaluate the clinical significance of the exprossion of epidermal growth factor receptor and transforming growth factor α in prostatic carinoma.Methods:Immunohistochemical method was used to detect epidermal growth factor receptor (EGFR) and transforming growth factor (TGF) α in 43 cases of prostatic carcinoma and 5 cases of normal prostatic tissues.Resutls:In normal prostatic tissues,EGFR and TGFα were mainly located in the epithelial cells and stromal cells respectively.The coexpression of EGFR and TGFα correlated significantly with the grade of the tumor (P< 0.01 ) and had a close correlation between them (r= 0.518 ),while the rate of them was 55.8 % in prostatic carcinomas,with which patients lived shorter than those with negative expression of both marks (P< 0.01 ).Conclusions:EGFR and TGFα in an autocrine fashion might play an important role in the corruption of the tumor and the failure of endocrinological therapy,both of them might serve as indicators to the clinical stage and prognosis of prostatic carcinoma.

关 键 词：前列腺肿瘤 表皮生长因子 受体 TGFΑ 

分 类 号：R737.250.2[医药卫生—肿瘤]