Th17、IL-17在幽门螺杆菌相关性胃癌中的研究进展  

Role of Th17 and IL-17 in Helicobacter pylori-related gastric carcinogenesis

作　　者：李伟[1] 杨桢[1] 黄德强[1] 吕农华[1] 

机构地区：[1]南昌大学第一附属医院消化内科 江西省消化系疾病研究所 江西省消化病研究重点实验室,江西省南昌市330006

出　　处：《世界华人消化杂志》2012年第11期936-940,共5页World Chinese Journal of Digestology

摘　　要：辅助性T细胞17(T helper cell17,Th17)是一种新发现的CD4+T细胞亚型,他以分泌白介素17(interleukin 17,IL-17)和表达转录因子RORγ为特征,在机体各种肿瘤和感染性疾病中起着重要作用.胃癌是一种与慢性幽门螺杆菌(Helicobacter pylori,H.pylori)感染密切相关的恶性肿瘤,死亡率极高.研究发现,Th17及其分泌的IL-17在H.pylori感染所致的慢性萎缩性胃炎、胃溃疡、不典型增生、肠上皮化生及胃癌的发生、发展中起着不可忽视的作用,相关研究为胃癌的早期诊断、个性化防治、瘤苗开发和预后评价提供了新思路.T helper 17（Th17） cells are a newly defined subset of CD4＋ effecter T cells characterized by the secretion of interleukin 17（IL-17） and transcription factor RORγ.They play significant roles in the pathogenesis of various tumors and bacterial infectious diseases.Gastric carcinoma is closely related to Helicobacter pylori（H.pylori） infection and has a very high mortality.Evidence shows that both Th17 and IL-17 play critical roles in the pathogenesis of H.pylori-associated gastric carcinoma and precancerous lesions.Elucidation of the roles of Th17 and IL-17 in H.pylori-related gastric carcinogenesis will provide new clues to the early diagnosis,personalized prevention and immunotherapy,vaccination and prognostic evaluation of gastric carcinoma.

关 键 词：辅助性T细胞17 白介素17 幽门螺杆菌 胃癌 癌前病变 

分 类 号：R735.2[医药卫生—肿瘤]