人工合成白细胞介素-1受体阻断剂对大鼠葡萄膜炎的影响  

Effects of synthetic interleukin-1 blockers on uveitis in rats

作　　者：周跃华[1] 李志辉[1] 安伟丽[1] George Chiou 

机构地区：[1]首都医科大学附属北京同仁医院眼科,100730 [2]Department of Medical Phamarcology

出　　处：《中华眼科杂志》2000年第1期62-64,共3页Chinese Journal of Ophthalmology

摘　　要：目的　观察人工合成的白细胞介素 1(interleukin 1,IL 1)受体阻断剂对大鼠葡萄膜炎的治疗作用。方法　选择 18只 (36只眼 )Sprague Dawley大鼠 ,采用酶联免疫吸附测定 (enzyme linkedimmunosorbentassay,ELISA)的方法 ,对人工合成的IL 1受体阻断剂治疗前、后的大鼠葡萄膜炎动物模型的视网膜内IL 1β和肿瘤坏死因子 (tumornecrosisfactor α ,TNFα)的含量进行测定。 结果　IL 1受体阻断剂 (CK 138,CK 139)治疗组 ,其视网膜内IL 1β和TNFα的含量均显著低于对照组的含量 (P<0 0 5 )。结论　人工合成的IL 1受体阻断剂 (CK 138,CK 139)对IL 1α所诱导的大鼠葡萄膜炎有一定的治疗作用。Objective To investigate the therapeutic action of synthetic interleukin 1 blockers on uveitis in rats Method Experiments were performed on 18 Spraque Dawley rats (36 eyes), and the retinal interleukin 1 β (IL 1 β) and tumor necrosis factor α (TNF α) were quantified by an enzyme linked immunoabsorbent assay (ELISA) before and after the rats with uveitis treated by synthetic interleukin 1 blockers Result The retinal IL 1 β and TNF α in rats with uveitis treated by synthetic IL 1 blockers (CK 138, 139) were significantly decreased than those treated by contrasting design Conclusion Synthetic IL 1 blockers (CK 138, 139) are effective in treatment of IL 1 α induced uveitis in the rat

关 键 词：葡萄膜炎 白细胞介素-1 肿瘤坏死因子 治疗 

分 类 号：R773[医药卫生—眼科]