gsp癌基因在国人肢端肥大症患者垂体肿瘤中的表达  

The expression of gsp oncogenes in the prtuitary tumors of chinese acromegalic patients

作　　者：白祥军[1] 雷霆[1] 刘暌[1] 薜德麟 

机构地区：[1]同济医科大学附属同济医院神经外科,武汉430030

出　　处：《中华实验外科杂志》2000年第1期53-54,共2页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金! ( 3 96 70 73 6 )

摘　　要：目的　观察gsp癌基因在国人肢端肥大症患者垂体肿瘤中的表达。 方法　采用PCR DNA直接序列分析方法 ,观察 18例肢端肥大症患者垂体肿瘤组织中 gsp癌基因的突变。 结果　 18例病人中 6例 (3 3 .3 % ) gsp癌基因阳性 ,4例位于编码Gsα 2 0 1号密码子上 (3例为CGT→TGT ,1例为CGT→CAT) ,2例位于编码Gsα 2 2 7号密码子上 (CAG→CTG)。结论　gsp癌基因在国人肢端肥大症患者垂体肿瘤中的表达率与国外一致 ,是垂体生长激素腺瘤发生的重要原因之一。Objective To investigate the expression of gsp oncogenes in the pituitary tumors of Chinese acromegalic patients. Methods\ The gsp oncogene mutation in the pituitary tumors of 18 cases of Chinese acromegaly was detected by using PCR DNA direct sequencing analysis. Results\ Of the 18 cases, 6 were gsp positive: 4 mutations were at codon Gsα201 (3 cases with CGT→TGT, 1 case with CGT→CAT), 2 mutations at codon Gsα227 (CAG→CTG). Conclusion\ The expression of gsp oncogenes in the prtuitary tumors of chinese acromegalic patients was similar to that in foreign patients. Gsp oncogenes was one of the main causes of the growth hormone-secreting pituitary tumor development.

关 键 词：肢端肥大症 gsp癌基因 垂体肿瘤 

分 类 号：R736.4[医药卫生—肿瘤]