急性脑梗塞病人血浆中一氧化氮与相关因素关系的研究  

Study on relationship between nitric oxide and the correlative factors in plasma of the patients with acute cerebral infarction

作　　者：吕晓红 王岩 李效宁 饶明俐 

机构地区：[1]吉林日报社卫生所

出　　处：《白求恩医科大学学报》2000年第1期39-41,共3页Journal of Norman Bethune University of Medical Science

摘　　要：目的 :从临床角度探讨一氧化氮 ( NO)在脑梗塞病人急性期中的作用机理。方法 :利用分光光度法及放射免疫分析法分别测定了脑梗塞病人急性期及恢复期血浆中的 NO、环 -磷酸鸟苷( c GMP)、降钙素 ( CT)、心钠素 ( ANP)的含量变化。结果 :脑梗塞病人急性期 NO及 c GMP、CT、ANP明显升高 ,NO与 c GMP、CT、ANP均呈显著正相关。结论 :NO在脑梗塞病人中具有双向作用Objective To study the action of nitric oxide and correlative factors on the patients with cerebral infarction in acute stage.Methods The content of nitric oxide (NO) in the plasma of cerebral infarct patients was detected with spectrophotometry and the content of cyclic guanosine (cGMP),Calcitonin (CT),atrialnatriuretic polypeptide (ANP) in the plasma of cerebral infarct patients was detected with automatic radio immunity analysis.Results The level of NO,cGMP,CT and ANP in the plasma of cerebral infarct patients in acute stage was significantly higher than that in covalescent stage and in control.The level of NO was positively correlated to the level of cGMP,CT and ANP significantly.Conclusion NO has the two way action in the acute stage of cerebral infarct patients:Its base release dose has physiologic function and the excessive NO has neurotoxicity.

关 键 词：脑梗塞 一氧化氮 相关因素 急性 

分 类 号：R743.330.2[医药卫生—神经病学与精神病学]