Rifaximin vs conventional oral therapy for hepatic encephalopathy:A meta-analysis  

作　　者：Karim M Eltawil Marie Laryea Kevork Peltekian Michele Molinari 

机构地区：[1]Department of Surgery and Transplantation, Queen Elizabeth Ⅱ Health Sciences Center, Dalhousie University [2]Department of Medicine, Hepatology and Transplantation, Queen Elizabeth Ⅱ Health Sciences Center, Dalhousie University

出　　处：《World Journal of Gastroenterology》2012年第8期767-777,共11页世界胃肠病学杂志（英文版）

摘　　要：AIM: To characterize the efficacy of rifaximin in the management of hepatic encephalopathy (HE) as several randomized controlled studies have shown contradictory results on its effectiveness in comparison to other oral agents. METHODS: We performed a systematic review and random effects meta-analysis of all eligible trials identifi ed through electronic and manual searches. Twelve randomized controlled trials met the inclusion criteria with a total of 565 patients. RESULTS: The clinical effectiveness of rifaximin was equivalent to disaccharides or other oral antibiotics[odds ratio (OR) 0.96; 95% CI: 0.94-4.08] but with a better safety profi le (OR 0.27; 95% CI: 0.12-0.59). At the completion of treatment protocols, patients receiving rifaximin showed lower serum ammonia levels [weighted mean difference (WMD) = -10.65; 95% CI: -23.4-2.1; P = 0.10], better mental status (WMD = -0.24; 95% CI: -0.57-0.08; P = 0.15) and less asterixis (WMD -0.1; 95% CI -0.26-0.07; P = 0.25) without reaching statistical signifi cance. On the other hand, other psychometric outcomes such as electroencephalographic response and grades of portosystemic encephalopathy were superior in patients treated with rifaximin in comparison to the control group (WMD = 0.21, 95% CI: -0.33-0.09, P = 0.0004; and WMD = -2.33, 95% CI: -2.68-1.98, P = 0.00001, respectively). Subgroup and sensitivity analysis did not show any signifi cant difference in the above fi ndings. CONCLUSION: Rifaximin appears to be at least as effective as other conventional oral agents for the treatment of HE with a better safety profi le.AIM： To characterize the efficacy of rifaximin in the management of hepatic encephalopathy （HE） as several randomized controlled studies have shown contradictory results on its effectiveness in comparison to other oral agents. METHODS： We performed a systematic review and random effects meta-analysis of all eligible trials identifi ed through electronic and manual searches. Twelve randomized controlled trials met the inclusion criteria with a total of 565 patients. RESULTS： The clinical effectiveness of rifaximin was equivalent to disaccharides or other oral antibiotics[odds ratio （OR） 0.96; 95% CI： 0.94-4.08] but with a better safety profi le （OR 0.27; 95% CI： 0.12-0.59）. At the completion of treatment protocols, patients receiving rifaximin showed lower serum ammonia levels [weighted mean difference （WMD） = -10.65; 95% CI： -23.4-2.1; P = 0.10], better mental status （WMD = -0.24; 95% CI： -0.57-0.08; P = 0.15） and less asterixis （WMD -0.1; 95% CI -0.26-0.07; P = 0.25） without reaching statistical signifi cance. On the other hand, other psychometric outcomes such as electroencephalographic response and grades of portosystemic encephalopathy were superior in patients treated with rifaximin in comparison to the control group （WMD = 0.21, 95% CI： -0.33-0.09, P = 0.0004; and WMD = -2.33, 95% CI： -2.68-1.98, P = 0.00001, respectively）. Subgroup and sensitivity analysis did not show any signifi cant difference in the above fi ndings. CONCLUSION： Rifaximin appears to be at least as effective as other conventional oral agents for the treatment of HE with a better safety profile.

关 键 词：Hepatic encephalopathy LACTULOSE Neo-mycin Non-absorbable disaccharides RIFAXIMIN 

分 类 号：R747.9[医药卫生—神经病学与精神病学]