Psychosocial determinants of irritable bowel syndrome  

作　　者：Teodora Surdea-Blaga Adriana Bban Dan L Dumitrascu 

机构地区：[1]2nd Medical Department,University of Medicine and Pharmacy IuliuHatieganu,Cluj-Napoca 400006,Romania [2]Department of Psychology,Babes-Bolyai University,Cluj-Napoca 400006,Romania

出　　处：《World Journal of Gastroenterology》2012年第7期616-626,共11页世界胃肠病学杂志（英文版）

基　　金：Supported by The Sectorial Operational Programme Human Resources Development,Contract POSDRU 6/1.5/S/3-,Doctoral studies: through science towards society

摘　　要：From a pure motor disorder of the bowel,in the past few years,irritable bowel syndrome (IBS) has become a multifactorial disease that implies visceral hypersensitivity,alterations at the level of nervous and humoral communications between the enteric nervous system and the central nervous system,alteration of the gut microflora,an increased intestinal permeability and minimum intestinal inflammation.Psychological and social factors can interfere with the communication between the central and enteric nervous systems,and there is proof that they are involved in the onset of IBS and influence the response to treatment and outcome.There is evidence that abuse history and stressful life events are involved in the onset of functional gastrointestinal disorders.In order to explain clustering of IBS in families,genetic factors and social learning mechanisms have been proposed.The psychological features,such as anxiety,depression as well as the comorbid psychiatric disorders,health beliefs and coping of patients with IBS are discussed in relation to the symptoms and outcome.From a pure motor disorder of the bowel, in the past few years, irritable bowel syndrome （IBS） has become a multifactorial disease that implies visceral hypersensitivity, alterations at the level of nervous and humoral communications between the enteric nervous system and the central nervous system, alteration of the gut microflora, an increased intestinal permeability and minimum intestinal inflammation. Psychological and social factors can interfere with the communication between the central and enteric nervous systems, and there is proof that they are involved in the onset of IBS and influence the response to treatment and outcome. There is evidence that abuse history and stressful life events are involved in the onset of functional gastrointestinal disorders. In order to explain clustering of IBS in families, genetic factors and social learning mechanisms have been proposed. The psychological features, such as anxiety, depression as well as the comorbid psychiatric disorders, health beliefs and coping of patients with IBS are discussed in relation to the symptoms and outcome.

关 键 词：ANXIETY Depressive symptoms Irritablebowel syndrome PERSONALITY Psychosocial factors Sexual abuse Stressful events 

分 类 号：R574[医药卫生—消化系统]