CCL7 and CCL21 overexpression in gastric cancer is associated with lymph node metastasis and poor prognosis  

作　　者：Tsann-Long Hwang Li-Yu Lee Chee-ChanWang Ying Liang Shu-Fang Huang Chi-Ming Wu 

机构地区：[1]Department of Sur-gery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan [2]Department of Medicine, Chang GungUniversity, Taoyuan 333, Taiwan [3]Department of Pathology, Chang Gung MemorialHospital, Taoyuan 333, Taiwan [4]Department of CosmeticScience, Vanung University, Chungli 320, Taiwan [5]Molecular Medicine Researeh Center, Chang GungUniversity, Taoyuan 333, Taiwan

出　　处：《World Journal of Gastroenterology》2012年第11期1249-1256,共8页世界胃肠病学杂志（英文版）

基　　金：Supported by Grants NSC 98-2314-B-238-001 from the National Science Council;VIT-98-CM-01 from Vanung University,Taiwan

摘　　要：AIM： To investigate how a complex network of CC chemokine ligands （eeLs） and their receptors influence the progression of tumor and metastasis.METHODS： In the present study, we used immunohistochemistry to examine the expression of CCL7, CCL8 and CCL21 in 194 gastric cancer samples and adjacent normal tissues. We analyzed their correlation with tumor metastasis, clinicopathologic parameters and clinical outcome.RESULTS： We found that the higher expression of CCL7 and CCL21 in cancer tissues than in normal tissues was significantly correlated with advanced depth of wall invasion, lymph node metastasis and higher tumornode metastasis stage. Moreover, Kaplan-Meier survival analysis revealed that CCL7 and CCL21 overexpression in cancer tissues was correlated with poor prognosis.CONCLUSION： These results suggest that overexpression of these two CC chemokine ligands is associ- ated with tumor metastasis and serves as a prognostic factor in patients with gastric cancer.AIM:To investigate how a complex network of CC chemokine ligands(CCLs) and their receptors influence the progression of tumor and metastasis.METHODS:In the present study,we used immunohistochemistry to examine the expression of CCL7,CCL8 and CCL21 in 194 gastric cancer samples and adjacent normal tissues.We analyzed their correlation with tumor metastasis,clinicopathologic parameters and clinical outcome.RESULTS:We found that the higher expression of CCL7 and CCL21 in cancer tissues than in normal tissues was significantly correlated with advanced depth of wall invasion,lymph node metastasis and higher tumor node metastasis stage.Moreover,Kaplan-Meier survival analysis revealed that CCL7 and CCL21 overexpression in cancer tissues was correlated with poor prognosis.CONCLUSION:These results suggest that overexpression of these two CC chemokine ligands is associated with tumor metastasis and serves as a prognostic factor in patients with gastric cancer.

关 键 词：CC chemokine Chemokine ligand 7  Che-mokine ligand 21 Gastric cancer Lymph node metas-tasis Poor prognosis 

分 类 号：R735.2[医药卫生—肿瘤]