2-芳氧基-噻吩并[2,3-d]嘧啶-4(3H)-酮衍生物的合成  

Synthesis of 2-Aryloxy-thienopyrimidin-4(3H)-one Derivatives

作　　者：郑爱华[1] 高海涛[1] 屈永年[1] 

机构地区：[1]湖北医药学院医学化学研究所,湖北十堰442000

出　　处：《化学与生物工程》2012年第4期32-33,53,共3页Chemistry & Bioengineering

基　　金：湖北省科技厅自然科学基金资助项目(2011CDB08301);湖北省教育厅科研项目(B20102103)

摘　　要：采用串联氮杂Wittig反应,合成了5种未见文献报道的2-芳氧基-噻吩并[2,3-d]嘧啶-4(3 H)-酮衍生物。首先由膦亚胺与芳基异氰酸酯反应得到碳二亚胺,再与取代酚在碳酸钾的催化下反应得到目标化合物,收率为62%～85%,并采用元素分析、IR、MS、1 HNMR等手段对目标化合物的结构进行了确证。Five kinds of 2-aryloxy-thienopyrimidin-4（3H）-one derivatives were synthesized by aza-Wittig reaction.Firstly carbodiimides were synthesized by iminophosphorane and aromatic isocyanates,then,the object compounds were synthesized by carbodiimides and substituted phenol in the presence of catalyst solid K2CO3 with yield of 62%~85%.And their structures were characterized by elemental analysis,IR,MS,1HNMR.

关 键 词：2-芳氧基-噻吩并[2 3-d]嘧啶-4(3H)-酮 氮杂WITTIG反应 合成 

分 类 号：O636.1[理学—高分子化学]