血清前列腺特异抗原检测在前列腺癌诊断中的意义探析  

Diagnostic value of prostatic neoplasms for prostatic cancer

作　　者：张杨[1] 

机构地区：[1]泰山医学院附属新泰医院,271200

出　　处：《实用医技杂志》2012年第4期352-354,共3页Journal of Practical Medical Techniques

摘　　要：目的探讨血清总前列腺特异抗原（t-PSA）、游离PSA（f-PSA）/t-PSA在前列腺癌（PCa）诊断中的意义。方法回顾性分析109例PCa与前列腺良性增生（BPH）患者血清t-PSA、f-PSA/t-PSA值在前列腺癌鉴别诊断中的意义。结果 PCa与BPH 2组患者间t-PSA、f-PSA/t-PSA值差异有统计学意义（P〈0.01）,当t-PSA含量在4.0~10.0μg/L时,2组患者间t-PSA水平差异无统计学意义（P〉0.05）,而f-PSA/t-PSA差异有统计学意义（P〈0.01）。当t-PSA含量在4.0~10.0μg/L时,f-PSA/t-PSA值分别为0.125,0.15,0.175时,对PCa的诊断敏感度为：56.0%,76.0%,88.0%;特异性为：93.8%,86.5%,78.2%。结论PCa患者t-PSA显著升高,f-PSA/t-PSA明显降低。当t-PSA含量在4.0~10.0μg/L时,t-PSA的诊断意义很小,选取f-PSA/t-PSA值为0.16作为临界值,既可保证较高的特异性,又不降低其敏感性。Objective To evaluate the diagnostic value of serum total prostatic specific antigen（t-PSA） and the ratio of free to t-PSA PSA for prostatic cancer（PCa）.Methods It was studied retrospectively 109 cases of PCa and 317 cases of benign prostatic hyperplasia（BPH） and compared the differences of t-PSA level and f/t ratio between two groups.Results The differences of serum t-PSA and F/T ratio between two groups were significant（P0.01）,When t-PSA level was 4.0-10.0 g/L,the difference of t-PSA between two groups was not significant（P0.05）,but in f/t ratio,the difference was significant（P0.01）.And when t-PSA level was 4.0-10.0 g/L,f/t ratio was 0.125,0.15,0.175 respectively,the sensitivity for diagnosing PCa were 56%,76%,88% respectively,the specificity of them were 93.8%,86.5%,78.2%,respectively.Conclusion The level of serum T-PSA in PCa significantly increased,the f/t ratio signi-ficantly decreased.If serum t-PSA level was 4.0-10.0 g/L,it was not valuable for diagnosing PCa.It has high sensitivity and specificity for diagnosing cancer（PCa） to select 0.16 as critical value of the f/t ratio.

关 键 词：前列腺肿瘤 前列腺增生 前列腺特异抗原 

分 类 号：R737.25[医药卫生—肿瘤]