芦笋老茎澄清汁对链脲佐菌素致糖尿病大鼠降糖作用的研究  

Hypoglycemic Activity of Clarified Asparaagus Juice in Streptozotocin Induced Diabetic Rats

作　　者：赵旌旌[1] 赵洪军[1] 赵頔[1] 王洁琼[1] 瞿伟菁[1] 

机构地区：[1]华东师范大学生命科学学院,上海200062

出　　处：《天然产物研究与开发》2012年第4期460-464,472,共6页Natural Product Research and Development

基　　金：国家自然科学基金项目(61172149)

摘　　要：本文评价了芦笋老茎澄清汁(CAJ)的降血糖作用,并对其降血糖机制进行了初步探讨。腹腔注射STZ制备类似1型糖尿病大鼠模型,以0.6,1.2和2.0 g/kg体重剂量的CAJ连续灌胃21 d,监测血糖,测定糖化血清蛋白、血清胰岛素、肝糖原、脂代谢及抗氧化系统部分相关指标。结果显示,CAJ可明显降低糖尿病大鼠血清中葡萄糖、糖化血清蛋白、总胆固醇和MDA含量,并显著提高受试模型鼠的血清胰岛素水平、肝糖原含量、血清SOD活性、肝脏SOD、GSH-Px和CAT的活性。上述结果表明CAJ可明显降低糖尿病大鼠的血糖水平,刺激胰岛素分泌,调节血脂,增强抗氧化能力。The present study was designed to evaluate the hypoglycemic effect of clarified juice of woody stem Asparagus officinalis L.（CAJ） in streptozotocin（STZ）-induced diabetic rats.Diabetes in rats was induced by a single intraperitoneal injection of STZ.0.6,1.2 and 2.0 g/kg body weight CAJ were orally administered to diabetic rats once a day lasting for 21 days.Results showed that administration of CAJ significantly lowered the fasting serum glucose,glycosylated serum protein,total cholesterol and malondialdehyde levels in diabetic rats,but markedly increased serum insulin level,hepatic glycogen content,activities of superoxide dismutase in serum and liver and activities of hepatic glutathione peroxidase and catalase.These results suggested that CAJ might have hypoglycemic,insulin-stimulating,hypotriglyceridemic and antioxidant effects in STZ induced diabetic rats.

关 键 词：芦笋老茎澄清汁(CAJ) 链脲佐菌素 糖尿病大鼠 降血糖作用 

分 类 号：R151.2[医药卫生—营养与食品卫生学] Q946.8[医药卫生—公共卫生与预防医学]