血管内皮生长因子的表达与亚洲胃癌患者病理学特征相关性的Meta分析  

A Meta-analysis of association of the expression of vascular endothelial growth factor with clinicopathologic features in Asian patients with gastric carcinoma

作　　者：李涛[1] 陈静[2,3] 李金平[1] 胡志强[1] 彭亮[2,3] 霍正浩[2,3] 刘奇伦[1] 

机构地区：[1]宁夏医科大学附属医院肿瘤外科,银川750004 [2]宁夏医科大学医学遗传与细胞生物学教研室,银川750004 [3]宁夏回族自治区生殖与遗传重点实验室,银川750004

出　　处：《肿瘤》2012年第4期295-300,共6页Tumor

摘　　要：目的:利用Meta分析定量评价血管内皮生长因子(vascular endothelial growth factor,VEGF)与亚洲胃癌患者临床病理学特征的关联性。方法:检索PubMed、中国知网(China National Knowledge In frastructure,CNKI)和维普全文期刊数据库中所有已发表胃癌组织中VEGF表达与病理学参数及其预后的相关性研究,应用STATA9.0SE软件进行不同组间VEGF表达比值比(oddratio,OR)和95%可信区间(95%confidence interval,CI)以及文献异质性和偏倚评估。结果:共纳入132篇研究文献;胃癌组织中VEGF的表达显著高于正常胃黏膜组织(P=0.000);且癌组织中VEGF的表达与肿瘤浸润深度(OR=3.32,95%CI=2.82～3.91)、淋巴转移(OR=3.52,95%CI=3.02～4.10)、远处转移(OR=2.88,95%CI=1.94～4.27)、静脉侵犯(OR=2.19,95%CI=1.68～2.85)和TNM分期(OR=3.98,95%CI=3.31～4.78)均有显著相关性。结论:VEGF蛋白可作为预测胃癌浸润转移以及评价患者预后的生物学指标,成为胃癌诊治中较有价值的早期分子标志物。Objective： The aim of this study was to evaluate the association of the expression of vascular endothelial growth factor （VEGF） with the clinicopathologic features in Asian patients with gastric carcinoma. Methods： The published studies related to the association of VEGF expression with the pathologic features in Asian patients with gastric carcinoma were searched in PubMed, China National Knowledge Infrastructure （CNKI） and WanFang databases. The bias and the heterogeneity of the included studies were analyzed, and the odds ratio （OR） and 95% confidence interval （CI） of VEGF expression related to different pathologic features were calculated by STATA 9.0SE software. Results： Totally, 132 studies were enrolled into the final meta analysis. The VEGF expression in the gastric cancer tissues was significantly higher than that in the normal gastric tissues （P = 0.000）. The VEGF expression was positively associated with the invasion depth of tumor （OR = 3.32; 95% CI = 2.82-3.91）, lymph node metastasis （OR = 3.52; 95% CI = 3.02-4.10）, distant metastasis （OR = 2.88; 95% CI =1.94-4.27）, vein invasion （OR = 2.19; 95% CI = 1.68-2.85）, and TNM staging （OR = 3.98; 95% CI = 3.31-4.78）. Conclusion： The results indicate that VEGF protein may be used as a biological marker to predict the invasion and metastasis of gastric cancer and its prognosis. VEGF may be a valuable predictor in the early diagnosis and treatment for gastric carcinoma.

关 键 词：胃肿瘤 血管内皮生长因子 META分析 亚洲 

分 类 号：R735.2[医药卫生—肿瘤]