脊髓小脑共济失调12型患者认知功能障碍的研究  

Study on cognitive impairment in patients with spinocerebellar ataxia type 12

作　　者：武传佳[1] 李海涛[1] 雷晶[1] 马建华[1] 关玉华 张小宁[1] 

机构地区：[1]新疆医科大学第一附属医院神经内科,乌鲁木齐830054 [2]新疆维吾尔自治区巴音郭楞蒙古自治州库尔勒市巴州人民医院神经内科

出　　处：《临床神经病学杂志》2012年第2期89-91,共3页Journal of Clinical Neurology

基　　金：新疆维吾尔自治区自然科学基金(2011211A063)

摘　　要：目的探讨脊髓小脑共济失调(SCA)12型患者是否存在认知功能障碍及其影响因素。方法采用蒙特利尔认知评估量表(MoCA)、简易精神状态检查量表(MMSE)对5例SCA12型患者(SCA12型组)及13名健康体检者(正常对照组)进行认知功能评估;采用国际协作共济失调评估量表(ICARS)进行共济失调严重程度评分。结果 MoCA评分结果显示,SCA12型组存在认知功能障碍5例(100%),正常对照组存在认知功能障碍10例(77%)。MMSE评分结果显示,SCA12型组存在认知功能障碍2例(40%),正常对照组存在认知功能障碍1例(7.7%)。SCA12型组MoCA和MMSE评分明显低于正常对照组(均P<0.05)。SCA12型组ICARS评分为23～75分,平均(42.6±21.0)分。正常对照组均无共济失调。Spearmans相关性分析显示,SCA12型患者MMSE评分与病程呈负相关(r=-0.894,P=0.041);MoCA抽象功能得分与病程呈负相关(r=-0.884,P=0.047)。结论 SCA12型患者可并发认知功能障碍,这可能与其病程较长有关。Objective To study whether the cognitive impairment exists in patients with spinocerebellar ataxia type 12（SCA12）,and its influential factors.Methods The cognitive function in 5 SCA12 paitients（SCA12 group） and 13 health controls（normal control group） were examined by Montreal cognitive assessment scale（MoCA） and mini mental state examination scale（MMSE）.The degree of ataxia was assessed by international cooperative ataxia rating scale（ICARS）.Results The MoCA score showed that there were 5 cases（100%） with cognitive impairment in SCA12 group and 10 cases（77%） with cognitive impairment in normal control group.The MMSE score showed that there were 2 cases（40%） with cognitive impairment in SCA12 group and 1 case（7.7%） with cognitive impairment in normal control group.The scores of MoCA and MMSE in SCA12 group were significantly lower than that in the normal control group（all P0.05）.The score of ICARS in SCA12 group was 23-75,and the average score was（42.6±21.0）.There was no ataxia in normal control group.Spearmans correlation analysis showed that the score of MMSE was negatively correlated with disease duration of SCA12 patients（r=-0.894,P=0.041）;the score of Abstraction in MoCA was negatively correlated with disease duration of SCA12 patients（r=-0.884,P=0.047）.Conclusion SCA12 patients can complicate with cognitive impairment,which may be correlated with its long duration of disease.

关 键 词：脊髓小脑共济失调12型 认知功能障碍 执行能力 延迟记忆 

分 类 号：R744[医药卫生—神经病学与精神病学]