原发性皮肤弥漫性大B细胞性淋巴瘤(腿型)17例临床病理分析  

Primary cutaneous diffuse large B-cell lymphoma,leg type:a clinicopathological analysis of 17 cases

作　　者：王焱[1] 朱芸[1] 饶秋[1] 石群立[1] 马恒辉[1] 余波[1] 周晓军[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院病理科,南京210002

出　　处：《诊断病理学杂志》2012年第2期85-87,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨原发性皮肤弥漫性大B细胞性淋巴瘤(腿型)(PCDLBCLLT)的临床病理特点。方法回顾性分析17例PCDLBCLLT的临床资料、组织学形态和免疫组化标记。结果 17例PCDLBCLLT的发病年龄为31～86岁,平均64.4岁;其中男性9例,女性8例,男女之比为1.1∶1;主要发生于腿部和躯干部。组织学表现为弥漫分布的肿瘤细胞,以中心母细胞和免疫母细胞为主,核分裂象易见,肿瘤组织不累及表皮。免疫组化:肿瘤细胞表达B细胞相关抗原,bcl-2、MUM1、FOX-P1和bcl-6(+),Ki-67增殖指数为60%～90%。结论 PCDLBCLLT是一种独特类型的大B细胞性淋巴瘤,预后较差。Objective To describe clinicopathologic features of primary cutaneous diffuse large B cell lymphoma,leg type（PCDLBCLLT）.Methods The clinical,pathologic and immunohistochemical features were investigated in 17 cases of PCDLBCLLT.Results Of 17 cases of PCDLBCLLT,9 were male and 8 were female,with a M：F ratio of 1.1：1,age ranged from 31 to 86 years（mean = 64.4 years）.Most cases occurred in leg and trunk.Morphologically,these lymphomas showed diffuse infiltrates,which often extended into the subcutaneous tissue.These infiltrates generally showed a monotonous population of centroblasts and immunoblasts.Mitotic figures were frequently observed.Immunohistochemically,tumor cells were positive for B-cell associated antigen.Bcl-2,bcl-6,MUM1 and FOX-P1 were expressed in most cases and Ki-67 presented a high level proliferation index.Conclusion PCDLBCLLT is a distinct entity of large B-cell lymphomas with a poor prognosis.

关 键 词：皮肤 原发性 弥漫性大B细胞性淋巴瘤 腿型 免疫组化 

分 类 号：R730.263[医药卫生—肿瘤]