可手术男性和女性乳腺癌的配对比较及临床特点  

Comparison of male and female resectable breast cancer and their clinicopathoiogical characteristics

作　　者：韩芸蔚[1] 常新忠[1] 温绍艳[1] 王欣[1] 

机构地区：[1]天津医科大学附属肿瘤医院乳腺一科,乳腺癌教育部防治重点实验室,天津市＂肿瘤防治＂重点实验室,300060

出　　处：《中华内分泌外科杂志》2012年第2期102-105,共4页Chinese Journal of Endocrine Surgery

摘　　要：目的探讨男性乳腺癌及与之配对的女性乳腺癌患者的临床病理、治疗特点，生存率差异及影响男性乳腺癌患者预后的因素。方法收集天津市肿瘤医院1995年1月至2008年12月63名男性乳腺癌的病例资料，并与126名同期的女性乳腺癌相匹配。匹配的标准是年龄、确诊时间、临床分期均相似。男性乳腺癌和女性乳腺癌患者临床病理指标的比较采用）（2检验和Fisher精确检验。生存分析采用Kaplan—Meier生存分析，2组生存率比较采用Log—rank检验，多因素分析采用Cox风险回归模型。结果10年无病生存率（DFS）男性乳腺癌患者为53．9％，女性乳腺癌患者为65．1％（P=0．047）；10年总生存率（OS）男性乳腺癌患者的为61．9％，女性乳腺癌患者为77％（P=0．032）。单因素分析结果：临床分期、手术方式及复发是影响男性患者预后的因素；多因素分析结果：临床分期是影响男性乳腺癌患者预后的独立因素。结论女性乳腺癌患者10年无病生存率和总生存率较男性乳腺癌患者好。临床分期是影响男性乳腺癌患者预后的独立因素。Objective To analyze clinicopathologieal characteristics and treatment of male breast cancer （MBC） and the matched female breast cancer （FBC）. To compare the survival difference between the 2 groups. To study the factors influencing the prognosis of MBC. Methods 63 MBC patients treated in Tianjin Medical U- niversity Cancer Institute and Hospital from Jan. 1995 to Dec. 2008 were enrolled in this study. Each MBC patient in the database was matched with 2 FBC patients. The matching criteria were with similar age, diagnosis time, and TNM stage. Chi-square test and Fisher exact test were employed to compare the clinicopatbologic characteris- tics of MBC and FBC. Kaplan-Meier method, Log-rank test, and Cox hazard regression model were employed re- spectively to make survival analysis, surival rate comparison and multivariate analysis. Results The 10-year dis- ease-free survival （DFS） rate was 53.9% for men and 65.1% for women （P = 0. 047）. The 10-year overall sur- vival （OS） rate was 61.9% for men and 77% for women （P =0. 032）. Univariate analysis showed TNM stage, surgical method and recurrence were factors influencing the prognosis of MBC patients. Multivariate analysis showed TNM stage was an independent factor influencing the prognosis of MBC patients. Conclusions FBC pa- tients bad a better 10-year OS rate and DFS rate than MBC patients. TNM stage is an independent factor influen- cing the prognosis of MBC patients.

关 键 词：男性乳腺癌 病理特征 预后 配对分析 

分 类 号：R737.9[医药卫生—肿瘤]