Skp2在大肠癌、大肠腺瘤及正常大肠黏膜中的表达及临床意义  

The expression and its clinical singnificance of Skp2 in colorectal carcinoma,adenoma and normal colorectal mucous membrane

作　　者：刘镜文[1] 魏茂富[1] 杨延莉[2] 

机构地区：[1]广东省东莞市虎门医院病理科,广东东莞523900 [2]广东省东莞市虎门医院内三科,广东东莞523900

出　　处：《中国现代医生》2012年第12期115-116,共2页China Modern Doctor

摘　　要：目的探讨大肠癌、大肠腺瘤和正常大肠黏膜中Skp2蛋白表达的临床意义。方法采用免疫组化方法,分别检测大肠癌、大肠腺瘤和正常大肠黏膜中Skp2蛋白的表达。结果大肠癌、大肠腺瘤和正常大肠黏膜中Skp2蛋白表达率分别为76%(57/75)、36.7%(11/30)、16%(4/25),大肠癌与大肠腺瘤、正常黏膜比较,差异有统计学意义(P<0.05),大肠腺瘤与正常黏膜比较,差异无统计学意义(P>0.05)。Skp2蛋白在有淋巴结转移的大肠癌组织中阳性率为92.3%(24/26),明显高于无淋巴结转移的大肠癌组织67.3%(33/49),差异有统计学意义(P<0.05);其表达与其他病理及临床因素无统计学意义(P>0.05)。结论 Skp2的表达与大肠癌的发生及转移有密切关系,阳性表达对预测大肠癌发生淋巴结转移具有指导意义。Objective To investigate the relationship between the expression of Skp2 in the normal coloreetal mucous membrane, colorectal adenoma ,carcinoma and clinicopathologic features. Methods The expression of Skp2 was detected in colorectal carcinoma , colorectal adenoma and normal colorectal mucous membrane by the immunohistochemieal staining. Results The frequency of Skp2 staining in the colorectaJ carcinoma was 76% （57/75）, being significantly higher than that of in normal eolorectal mucous membrane and adenoma 16% （4/25）, 36.7% （11/30）, respectively （P 〈 0.05）. The positive rate of Skp2 immunostaining was 92.3% in patients with lymphytic metastasis, and was significantly higher than that of in patients without lymphytic metastasis 67.3%（P 〈 0.05）. Skp2 expression was irrelated to other clinicopathologic features（P 〉0.05）. Conclusion Skp2 is significantly related to the metastasis of colorectal carcinoma and over expression of Skp2 has some predicting significance of metastasis for colorectal cancer.

关 键 词：SKP2 大肠腺瘤 大肠癌 正常大肠黏膜 

分 类 号：R735.34[医药卫生—肿瘤]